Literature DB >> 12407674

Dealing with competing risks: testing covariates and calculating sample size.

Melania Pintilie1.   

Abstract

It is universally agreed that Kaplan-Meier estimates overestimate the probability of the event of interest in the presence of competing risks. Kalbfleisch and Prentice recommend using the cumulative incidence as an estimate of the probability of an event of interest. However, there is no consensus on how to test the effect of a covariate in the presence of competing risks. Using simulations, this paper illustrates that the Cox proportional hazards model gives valid results when employed in testing the effect of a covariate on the hazard rate and when estimating the hazard ratio. A method to calculate the sample size for testing the effect of a covariate on outcome in the presence of competing risks is also provided. Copyright 2002 John Wiley & Sons, Ltd.

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Year:  2002        PMID： 12407674     DOI： 10.1002/sim.1271

Source DB:  PubMed          Journal:  Stat Med        ISSN： 0277-6715            Impact factor:   2.373


  19 in total

1.  End-stage renal disease risk equations for Hong Kong Chinese patients with type 2 diabetes: Hong Kong Diabetes Registry.

Authors:  X L Yang; W Y So; A P S Kong; P Clarke; C S Ho; C W K Lam; M H L Ng; R R Lyu; D D Yin; C C Chow; C S Cockram; P C Y Tong; J C N Chan
Journal:  Diabetologia       Date:  2006-08-30       Impact factor: 10.122

2.  Competing event risk stratification may improve the design and efficiency of clinical trials: secondary analysis of SWOG 8794.

Authors:  Kaveh Zakeri; Brent S Rose; Sachin Gulaya; Anthony V D'Amico; Loren K Mell
Journal:  Contemp Clin Trials       Date:  2012-10-11       Impact factor: 2.226

3.  Associations of hyperglycemia and insulin usage with the risk of cancer in type 2 diabetes: the Hong Kong diabetes registry.

Authors:  Xilin Yang; Gary T C Ko; Wing Yee So; Ronald C W Ma; Linda W L Yu; Alice P S Kong; Hailu Zhao; Chun-Chung Chow; Peter C Y Tong; Juliana C N Chan
Journal:  Diabetes       Date:  2010-02-25       Impact factor: 9.461

4.  Prospective predictors of return to work in the 5 years after hematopoietic cell transplantation.

Authors:  Anne C Kirchhoff; Wendy Leisenring; Karen L Syrjala
Journal:  J Cancer Surviv       Date:  2010-03       Impact factor: 4.442

5.  Choice and interpretation of statistical tests used when competing risks are present.

Authors:  James J Dignam; Maria N Kocherginsky
Journal:  J Clin Oncol       Date:  2008-08-20       Impact factor: 44.544

6.  Independent associations between low-density lipoprotein cholesterol and cancer among patients with type 2 diabetes mellitus.

Authors:  Xilin Yang; WingYee So; Gary T C Ko; Ronald C W Ma; Alice P S Kong; Chun-Chung Chow; Peter C Y Tong; Juliana C N Chan
Journal:  CMAJ       Date:  2008-08-26       Impact factor: 8.262

Review 7.  Novel Composite Endpoints after Allogeneic Hematopoietic Cell Transplantation.

Authors:  Haesook T Kim; Brent Logan; Daniel J Weisdorf
Journal:  Transplant Cell Ther       Date:  2021-05-15

8.  Sample size determination for jointly testing a cause-specific hazard and the all-cause hazard in the presence of competing risks.

Authors:  Qing Yang; Wing K Fung; Gang Li
Journal:  Stat Med       Date:  2017-12-27       Impact factor: 2.497

9.  Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001.

Authors:  Paul D Brown; Vinai Gondi; Stephanie Pugh; Wolfgang A Tome; Jeffrey S Wefel; Terri S Armstrong; Joseph A Bovi; Cliff Robinson; Andre Konski; Deepak Khuntia; David Grosshans; Tammie L S Benzinger; Deborah Bruner; Mark R Gilbert; David Roberge; Vijayananda Kundapur; Kiran Devisetty; Sunjay Shah; Kenneth Usuki; Bethany Marie Anderson; Baldassarre Stea; Harold Yoon; Jing Li; Nadia N Laack; Tim J Kruser; Steven J Chmura; Wenyin Shi; Snehal Deshmukh; Minesh P Mehta; Lisa A Kachnic
Journal:  J Clin Oncol       Date:  2020-02-14       Impact factor: 50.717

10.  Silver-impregnated, antibiotic-impregnated or non-impregnated ventriculoperitoneal shunts to prevent shunt infection: the BASICS three-arm RCT.

Authors:  Conor L Mallucci; Michael D Jenkinson; Elizabeth J Conroy; John C Hartley; Michaela Brown; Tracy Moitt; Joanne Dalton; Tom Kearns; Michael J Griffiths; Giovanna Culeddu; Tom Solomon; Dyfrig Hughes; Carrol Gamble
Journal:  Health Technol Assess       Date:  2020-03       Impact factor: 4.014
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