BACKGROUND: The purpose of this study was to examine the long-term survival and causes of death in patients who survive the first year after liver transplantation. METHODS: The focus of the analysis was 433 patients who survived for at least 1 year after liver transplantation between November 1, 1984, and December 31, 2001. A total of 586 liver transplants were performed in 542 patients during this time period. The overall 1-, 5-, and 10-year survivals and the 5- and 10-year survivals for those patients who lived for a year were analyzed on the basis of Kaplan-Meier survival estimates. Factors examined included diagnosis, sex, age, and retransplantation. The causes of death were also analyzed. RESULTS: The overall 1-, 5-, and 10-year survivals were 85%, 73%, and 55%, respectively. The 5- and 10-year survivals for those patients who lived for a year were 86% and 65%, respectively. Fifty-one percent of the causes of late death were graft-related, 71% from recurrent primary disease. Cardiovascular events and de novo malignancies were responsible for 65% of the nongraft-related deaths. CONCLUSIONS: The long-term survival in patients who survive for the first year after liver transplantation is excellent. Recurrent primary disease is responsible for the majority of graft-related deaths. Cardiovascular events and de novo malignancy cause most of the nongraft-related deaths.
BACKGROUND: The purpose of this study was to examine the long-term survival and causes of death in patients who survive the first year after liver transplantation. METHODS: The focus of the analysis was 433 patients who survived for at least 1 year after liver transplantation between November 1, 1984, and December 31, 2001. A total of 586 liver transplants were performed in 542 patients during this time period. The overall 1-, 5-, and 10-year survivals and the 5- and 10-year survivals for those patients who lived for a year were analyzed on the basis of Kaplan-Meier survival estimates. Factors examined included diagnosis, sex, age, and retransplantation. The causes of death were also analyzed. RESULTS: The overall 1-, 5-, and 10-year survivals were 85%, 73%, and 55%, respectively. The 5- and 10-year survivals for those patients who lived for a year were 86% and 65%, respectively. Fifty-one percent of the causes of late death were graft-related, 71% from recurrent primary disease. Cardiovascular events and de novo malignancies were responsible for 65% of the nongraft-related deaths. CONCLUSIONS: The long-term survival in patients who survive for the first year after liver transplantation is excellent. Recurrent primary disease is responsible for the majority of graft-related deaths. Cardiovascular events and de novo malignancy cause most of the nongraft-related deaths.
Authors: Samarth S Patel; Mohammad B Siddiqui; Anchalia Chadrakumaran; Masoud Faridnia; Fei-Pi Lin; Jose Hernandez Roman; Salvatore Carbone; John Laurenzo; Joseph Clinton; Danielle Kirkman; Susan Wolver; Francesco Celi; Chandra Bhati; Mohammad S Siddiqui Journal: Dig Dis Sci Date: 2019-08-22 Impact factor: 3.199
Authors: Kiran Bambha; W Ray Kim; Charles B Rosen; Rachel A Pedersen; Cynthia Rys; Christopher P Kolbert; Julie M Cunningham; Terry M Therneau Journal: Mayo Clin Proc Date: 2010-09 Impact factor: 7.616
Authors: Miguel Jiménez-Pérez; Rocío González-Grande; Edith Omonte Guzmán; Víctor Amo Trillo; Juan Miguel Rodrigo López Journal: World J Gastroenterol Date: 2016-07-28 Impact factor: 5.742
Authors: L Quteineh; P-Y Bochud; D Golshayan; S Crettol; J-P Venetz; O Manuel; Z Kutalik; A Treyer; R Lehmann; N J Mueller; I Binet; C van Delden; J Steiger; P Mohacsi; J-F Dufour; P M Soccal; M Pascual; C B Eap Journal: Pharmacogenomics J Date: 2015-12-08 Impact factor: 3.550