Literature DB >> 12406649

Pharmacogenomics of organic anion-transporting polypeptides (OATP).

Rommel G Tirona1, Richard B Kim.   

Abstract

The organic anion-transporting polypeptides (OATP) represent a family of proteins responsible for the membrane transport of a large number of endogenous and xenobiotic compounds with diverse chemical characteristics. OATPs are expressed in liver, kidney, brain and intestine suggesting that they may play a critical role in drug disposition. Naturally occurring polymorphisms in OATPs are currently being identified and for some, in vitro transport activities have been characterized. In this article, we review the molecular, biochemical and pharmacological aspects of known human OATPs including the presence and functional relevance of genetic polymorphisms.

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Year:  2002        PMID： 12406649     DOI： 10.1016/s0169-409x(02)00077-7

Source DB:  PubMed          Journal:  Adv Drug Deliv Rev        ISSN： 0169-409X            Impact factor:   15.470


  15 in total

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