| Literature DB >> 12406644 |
Hong-Guang Xie1, Harish C Prasad, Richard B Kim, C Michael Stein.
Abstract
Cytochrome P-450 (CYP) 2C9 CYP2C9 is a polymorphically expressed enzyme responsible for the metabolism of several clinically important drugs, some with a low therapeutic index. This review summarizes the structure-function relationship of the CYP2C9 promoter and coding regions, known polymorphisms, the functional significance of various CYP2C9 alleles in vitro and in vivo, and their population frequencies. In addition, possible molecular mechanisms underlying ethnic variability in the metabolism of CYP2C9 substrate drugs are discussed.Entities:
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Year: 2002 PMID： 12406644 DOI： 10.1016/s0169-409x(02)00076-5
Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470