Literature DB >> 12406562

Potent cytotoxic effect of the trans10, cis12 isomer of conjugated linoleic acid on rat hepatoma dRLh-84 cells.

Masao Yamasaki1, Hitomi Chujo, Yasuko Koga, Ayana Oishi, Tatsuya Rikimaru, Mitsuo Shimada, Keizo Sugimachi, Hirofumi Tachibana, Koji Yamada.   

Abstract

We evaluated the cytotoxic effect of conjugated linoleic acid (CLA) on rat hepatoma dRLh-84 cells in vitro. When cells were cultured in the presence of CLA, strong cytotoxic effect on dRLh-84 cells was recognized at 1 microM level compared to the control vehicle group, and trans10, cis12-CLA but not cis9, trans11-CLA was shown to be an active isomer for inducing this effect. Increase of the sub-G1 population and activation of caspase-3 and 9 accompanied with a time-dependent cleavage of poly(ADP-ribose) polymerase were recognized in dRLh-84 cells treated with trans10, cis12-CLA. In addition, we could see nuclear fragmentation in dRLh-84 cells treated with trans10, cis12-CLA by laser scanning confocal microscopy observation. Cytotoxic effect of trans10, cis12-CLA on normal hepatocytes was weaker than on dRLh-84 cells. These data indicate trans10, cis12-CLA has a potent cytotoxic effect on dRLh-84 cells through at least in part by an apoptotic pathway.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12406562     DOI： 10.1016/s0304-3835(02)00459-7

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  10 in total

1.  Conjugated linoleic acid induces apoptosis of murine mammary tumor cells via Bcl-2 loss.

Authors:  Lihui Ou; Clement Ip; Barbara Lisafeld; Margot M Ip
Journal:  Biochem Biophys Res Commun       Date:  2007-03-26       Impact factor: 3.575

2.  Conjugated linoleic acid suppresses colon carcinogenesis in azoxymethane-pretreated rats with long-term feeding of diet containing beef tallow.

Authors:  Ryosuke Shiraishi; Ryuichi Iwakiri; Takehiro Fujise; Tsukasa Kuroki; Takashi Kakimoto; Tooru Takashima; Yasuhisa Sakata; Seiji Tsunada; Yutaka Nakashima; Teruyoshi Yanagita; Kazuma Fujimoto
Journal:  J Gastroenterol       Date:  2010-02-10       Impact factor: 7.527

Review 3.  Anti-cancer activities of ω-6 polyunsaturated fatty acids.

Authors:  Yi Xu; Steven Y Qian
Journal:  Biomed J       Date:  2014 May-Jun       Impact factor: 4.910

4.  Conjugated linoleic acid-induced apoptosis in mouse mammary tumor cells is mediated by both G protein coupled receptor-dependent activation of the AMP-activated protein kinase pathway and by oxidative stress.

Authors:  Yung-Chung Hsu; Margot M Ip
Journal:  Cell Signal       Date:  2011-07-23       Impact factor: 4.315

5.  Preparation and fractionation of conjugated trienes from alpha-linolenic acid and their growth-inhibitory effects on human tumor cells and fibroblasts.

Authors:  Miki Igarashi; Teruo Miyazawa
Journal:  Lipids       Date:  2005-01       Impact factor: 1.880

6.  9-trans, 11-trans-CLA: antiproliferative and proapoptotic effects on bovine endothelial cells.

Authors:  Kuan-Lin Lai; Armida P Torres-Duarte; Jack Y Vanderhoek
Journal:  Lipids       Date:  2005-11       Impact factor: 1.880

7.  Cytotoxity of the trans10,cis12 isomer of conjugated linoleic acid on rat hepatoma and its modulation by other fatty acids, tocopherol, and tocotrienol.

Authors:  Masao Yamasaki; Eri Nishida; Shinsuke Nou; Hirofumi Tachibana; Koji Yamada
Journal:  In Vitro Cell Dev Biol Anim       Date:  2005 Jul-Aug       Impact factor: 2.416

8.  Oleic acid prevents apoptotic cell death induced by trans10, cis12 isomer of conjugated linoleic acid via p38 MAP kinase dependent pathway.

Authors:  Masao Yamasaki; Hirofumi Tachibana; Arisa Yamada; Yukari Ochi; Harishkumar Madhyastha; Kazuo Nishiyama; Koji Yamada
Journal:  In Vitro Cell Dev Biol Anim       Date:  2008-06-21       Impact factor: 2.416

9.  Trans10,cis12 conjugated linoleic acid inhibits proliferation and migration of ovarian cancer cells by inducing ER stress, autophagy, and modulation of Src.

Authors:  Mian M K Shahzad; Mildred Felder; Kai Ludwig; Hannah R Van Galder; Matthew L Anderson; Jong Kim; Mark E Cook; Arvinder K Kapur; Manish S Patankar
Journal:  PLoS One       Date:  2018-01-11       Impact factor: 3.240

10.  Heterologous expression of linoleic acid isomerase from Propionibacterium acnes and anti-proliferative activity of recombinant trans-10, cis-12 conjugated linoleic acid.

Authors:  Eva Rosberg-Cody; Mark C Johnson; Gerald F Fitzgerald; Paul R Ross; Catherine Stanton
Journal:  Microbiology (Reading)       Date:  2007-08       Impact factor: 2.777
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.