| Literature DB >> 12406554 |
Joanne E Curran1, Stephen R Weinstein, Lyn R Griffiths.
Abstract
Nuclear factor kappa-beta (NF-kappaB) is a transcription factor responsible for modulating the expression of many genes involved in cell proliferation, differentiation, apoptosis and metastasis. NF-kappaB interacts with IkappaB inhibitory proteins to regulate gene expression. This study investigated common variants within the genes coding for NF-kappaB and IkappaB, NFKB1 and NFKBIA, for involvement in sporadic breast cancer. Genotypes were determined in a population of breast cancer affected individuals and age-matched controls. Results do not support an involvement of the tested NFKB1 and NFKBIA polymorphisms in susceptibility to sporadic breast cancer, in the tested Caucasian population.Entities:
Mesh：
Substances：
Year: 2002 PMID： 12406554 DOI： 10.1016/s0304-3835(02)00460-3
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679