| Literature DB >> 12406547 |
Robert T Chatterton1, John P Lydon, Rajendra G Mehta, Esnar T Mateo, Ashley Pletz, V Craig Jordan.
Abstract
Glands of wild-type (WT) and progesterone receptor knockout (PRKO) mice were exposed to 7,12-dimethylbenz[a]anthracene (DMBA) while cultured in serum-free medium containing insulin, prolactin, aldosterone, and cortisol. Glands of WT but not PRKO mice responded to DMBA with epithelial hyperplasia after 10 days in this medium. After culture without prolactin and adrenocortical hormones for an additional 14 days, hyperplastic lesions were present only in glands of WT mice. We conclude that in the absence of PR, epithelial structures are resistant to the carcinogenic action of DMBA.Entities:
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Year: 2002 PMID： 12406547 DOI： 10.1016/s0304-3835(02)00461-5
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679