| Literature DB >> 12406186 |
Kunikazu Tanji1, Fumiaki Mori, Tadaatsu Imaizumi, Hidemi Yoshida, Tomoh Matsumiya, Wakako Tamo, Makoto Yoshimoto, Hiroki Odagiri, Mutsuo Sasaki, Hitoshi Takahashi, Kei Satoh, Koichi Wakabayashi.
Abstract
Alpha-synuclein was originally identified as the presynaptic nerve terminal protein. Recently, we reported that alpha-synuclein is also expressed in cultured human astrocytes and that its levels are increased by stimulation with interleukin-1beta, suggesting that it may be involved in inflammatory processes. We therefore investigated the effect of inflammatory stimuli on alpha-synuclein expression in human macrophages. Alpha-synuclein mRNA and protein were detected in cultured human macrophages and levels of alpha-synuclein protein were increased by stimulation with lipopolysaccharide and interleukin-1beta in a time- and concentration-dependent manner. Immunofluorescent staining showed that alpha-synuclein protein was expressed within the cytoplasm and nucleus. Furthermore, alpha-synuclein immunoreactivity was present in alveolar macrophages from human lung tissues. These findings suggest that the function of alpha-synuclein is not exclusive to the nervous system and that alpha-synuclein may play a role in inflammatory processes and immune responses.Entities:
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Year: 2002 PMID： 12406186 DOI： 10.1046/j.1440-1827.2002.01385.x
Source DB: PubMed Journal: Pathol Int ISSN： 1320-5463 Impact factor: 2.534