Literature DB >> 12406090

Molecular cytogenetics characterization of a novel translocation involving chromosomes 17 and 19 in a Ph+ adult acute lymphoblastic leukaemia.

Giorgina Specchia1, Francesco Albano, Luisa Anelli, Clelia Tiziana Storlazzi, Giuseppe Cimino, Arcangelo Liso, Antonella Zagaria, Vincenzo Liso, Mariano Rocchi.   

Abstract

We report a case of positive Philadelphia chromosome adult acute lymphoblastic leukaemia with a novel unbalanced translocation t(17;19), leading to trisomy of 17q21-qter. The patient did not obtain complete haematological response and died a few months after diagnosis. The significance of the 17q21-qter trisomy, resulting from this novel translocation, and its possible role in the progression of the leukaemia is discussed.

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Year:  2002        PMID: 12406090     DOI: 10.1046/j.1365-2141.2002.03846.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN: 0007-1048            Impact factor:   6.998


  1 in total

1.  A rare variant of t(17;19) in a case of Philadelphia positive adult acute lymphoblastic leukemia presenting with disseminated intravascular coagulation.

Authors:  Moeinadin Safavi; Akbar Safaei; Mahnaz Lotfi
Journal:  Blood Res       Date:  2018-03-27
  1 in total

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