Literature DB >> 12405818

Ruthenium-catalyzed s-propargylation of thiols enables the rapid synthesis of propargylic sulfides.

Teruyuki Kondo1, Yusuke Kanda, Atsushi Baba, Kenji Fukuda, Ayako Nakamura, Kenji Wada, Yasuhiro Morisaki, Take-Aki Mitsudo.   

Abstract

A new and highly efficient catalytic system based on CpRuClL2 is proposed for the S-propargylation of thiols by propargylic carbonates under neutral conditions, in which specific requirements inherent to the different reactivities of aliphatic and aromatic thiols are achieved by tuning both the nature of the ancillary ligand L and the experimental conditions.

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Year:  2002        PMID: 12405818     DOI: 10.1021/ja027750o

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN: 0002-7863            Impact factor:   15.419


  1 in total

Review 1.  In situ activation of therapeutics through bioorthogonal catalysis.

Authors:  Wenjie Wang; Xianzhi Zhang; Rui Huang; Cristina-Maria Hirschbiegel; Huaisong Wang; Ya Ding; Vincent M Rotello
Journal:  Adv Drug Deliv Rev       Date:  2021-07-29       Impact factor: 17.873

  1 in total

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