BACKGROUND: As the clinical features of sarcoidosis vary among patients from different ethnic groups and geographic areas, local reports are of great interest. PATIENTS AND METHODS: The files of 120 patients (72 females, 48 males), 65% of Jewish and 35% of Arab origin, with a mean age at diagnosis of 49.7 +/- 11.1 years, with biopsy-proven sarcoidosis, and residents of northern Israel were evaluated and disease parameters recorded. RESULTS: The mean annual incidence between 1980-1996 was 0.8/100,000. Most patients presented with pulmonary symptoms of at least one month's duration. Thoracic and extra-thoracic involvement was found in 90% and 47% of patients, respectively. Radiographic stage 0,1,2,3,4 disease was found in 9.2, 31.7, 18.3, 37.5 and 3.3% of the patients respectively. Sixty-two patients received medical therapy, mostly for pulmonary involvement. The majority of patients recovered without sequelae. Six patients died from sarcoidosis during the follow-up period (cardiac: 2, pulmonary: 4), providing a 5% mortality rate. CONCLUSIONS: Sarcoidosis in northern Israel is a fairly uncommon condition that occurs mainly in older patients with female predominance. Patients in this area have a higher incidence of clinically significant pulmonary involvement necessitating medical therapy as compared to other parts of the world.
BACKGROUND: As the clinical features of sarcoidosis vary among patients from different ethnic groups and geographic areas, local reports are of great interest. PATIENTS AND METHODS: The files of 120 patients (72 females, 48 males), 65% of Jewish and 35% of Arab origin, with a mean age at diagnosis of 49.7 +/- 11.1 years, with biopsy-proven sarcoidosis, and residents of northern Israel were evaluated and disease parameters recorded. RESULTS: The mean annual incidence between 1980-1996 was 0.8/100,000. Most patients presented with pulmonary symptoms of at least one month's duration. Thoracic and extra-thoracic involvement was found in 90% and 47% of patients, respectively. Radiographic stage 0,1,2,3,4 disease was found in 9.2, 31.7, 18.3, 37.5 and 3.3% of the patients respectively. Sixty-two patients received medical therapy, mostly for pulmonary involvement. The majority of patients recovered without sequelae. Six patients died from sarcoidosis during the follow-up period (cardiac: 2, pulmonary: 4), providing a 5% mortality rate. CONCLUSIONS:Sarcoidosis in northern Israel is a fairly uncommon condition that occurs mainly in older patients with female predominance. Patients in this area have a higher incidence of clinically significant pulmonary involvement necessitating medical therapy as compared to other parts of the world.
Authors: Yan Yatsynovich; Damian Valencia; Mikhail Petrov; Juan David Linares; Mufti M Rahman; Nathaniel Dittoe Journal: Curr Treat Options Cardiovasc Med Date: 2018-08-07
Authors: Cesia Gallegos; Evangelos K Oikonomou; Alyssa Grimshaw; Mridu Gulati; Bryan D Young; Edward J Miller Journal: Int J Cardiol Heart Vasc Date: 2021-04-29
Authors: Carmen Pizarro; Folke Kluenker; Darius Dabir; Daniel Thomas; Florian C Gaertner; Markus Essler; Christian Grohé; Georg Nickenig; Dirk Skowasch Journal: ESC Heart Fail Date: 2017-12-12