Neuroprotective effects of low-doses of aspirin.

Aspirin appears to have a neuroprotective role against glutamate excitotoxicity. In fact, recent animal studies have demonstrated the neuroprotective role of acetylsalicylic acid (ASA) against glutamatergic excitants. It has been pointed out that ASA is neuroprotective against hypoxic hypoxia, chemical hypoxia and also delays the decline of intracellular ATP. Prostaglandins may cause convulsions and high-doses of aspirin appear to protect neurons from excitotoxicity. A case is reported of a woman whose electroencephalogram (EEG) abnormalities reversed and whose psychological symptomatology regressed after treatment with low-doses of aspirin. This appears to be the first description of a disappearance of EEG abnormalities with low-doses of aspirin. The neuroprotective effect of ASA could be of extreme importance in metabolic neuronal disfunction, reversing both clinical symptoms and EEG genetic anomalies: it is probably due to transient neurotransmitter concentration disequilibrium caused by subclinical hypoxic cortical suffering. Copyright 2001 John Wiley & Sons, Ltd.