Literature DB >> 12404013

Chocolate, an effective means of oral drug delivery in rats.

Karen M Huang-Brown1, Faisal A Guhad.   

Abstract

Oral gavage is an important procedure for drug discovery and efficacy studies using rodents. However, there are welfare issues related to the use of the method by inexperienced persons or for long-term studies. The authors describe an effective method of administering drugs to rats by mixing the drug with chocolate to provide a consistent and reliable method of oral drug delivery to large groups of rats for a long period of time.

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Year:  2002        PMID: 12404013     DOI: 10.1038/5000197

Source DB:  PubMed          Journal:  Lab Anim (NY)        ISSN: 0093-7355            Impact factor:   12.625


  5 in total

1.  Alternative method of oral dosing for rats.

Authors:  Zeenat Atcha; Claire Rourke; Aveline Hp Neo; Catherine Wh Goh; Jean Sk Lim; Chiu-Cheong Aw; Edward R Browne; Darrel J Pemberton
Journal:  J Am Assoc Lab Anim Sci       Date:  2010-05       Impact factor: 1.232

2.  Voluntary ingestion of antiparasitic drugs emulsified in honey represents an alternative to gavage in mice.

Authors:  Tatiana Küster; Beatrice Zumkehr; Corina Hermann; Regula Theurillat; Wolfgang Thormann; Bruno Gottstein; Andrew Hemphill
Journal:  J Am Assoc Lab Anim Sci       Date:  2012-03       Impact factor: 1.232

3.  Voluntary Oral Administration of Losartan in Rats.

Authors:  Lucília N Diogo; Inês V Faustino; Ricardo A Afonso; Sofia A Pereira; Emília C Monteiro; Ana I Santos
Journal:  J Am Assoc Lab Anim Sci       Date:  2015-09       Impact factor: 1.232

4.  Voluntary oral dosing for precise experimental compound delivery in adult rats.

Authors:  Kyle C Chesler; Cara T Motz; Katie L Bales; Rachael A Allen; Harrison K Vo; Machelle T Pardue
Journal:  Lab Anim       Date:  2021-08-14       Impact factor: 2.908

5.  Enriched environment experience overcomes learning deficits and depressive-like behavior induced by juvenile stress.

Authors:  Yana Ilin; Gal Richter-Levin
Journal:  PLoS One       Date:  2009-01-30       Impact factor: 3.240

  5 in total

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