Peripheral actions of leptin and its involvement in disease.

The discovery of leptin is broadening our understanding of the mechanisms underlying neuroendocrine function. To date, most investigations have focused on the effects of leptin on food intake control and body weight homeostasis with attention primarily focused on the central effects of leptin. However, the almost ubiquitous distribution of leptin receptors in peripheral tissues provides a fertile area for investigation and a more dynamic view of leptin is starting to unfold. Thus, leptin has generated enormous interest in the interaction as well as integration between brain targets and peripheral signals. The scientific evidence supporting the direct peripheral effects of leptin on angiogenesis, wound healing, lipolysis, blood pressure homeostasis, and satiety control is reviewed.