Literature DB >> 12402499

CDKs and CKIs: molecular targets for tissue remodelling.

Elizabeth G Nabel1.   

Abstract

Effective tissue remodelling is essential to the survival of adult organs. Many of the signalling pathways that control these cellular decisions are regulated by nuclear interactions of cell-cycle proteins. Molecules that target cyclin-dependent kinases (CDKs) or CDK inhibitors (CKIs) represent a new class of therapeutic agents that influence tissue remodelling in several organ systems. An understanding of their cell-specific functions is leading to the development of exciting and bold approaches to the treatment cancer, cardiovascular disease and other diseases.

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Year:  2002        PMID： 12402499     DOI： 10.1038/nrd869

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  17 in total

Review 1.  Current understanding of coronary in-stent restenosis. Pathophysiology, clinical presentation, diagnostic work-up, and management.

Authors:  T M Schiele
Journal:  Z Kardiol       Date:  2005-11

2.  CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development.

Authors:  Yo-Taro Shirai; Anna Mizutani; Saori Nishijima; Masafumi Horie; Chisato Kikuguchi; Olga Elisseeva; Tadashi Yamamoto
Journal:  Oncogene       Date:  2018-12-10       Impact factor: 9.867

3.  Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions.

Authors:  Navjotsingh Pabla; Alice A Gibson; Mike Buege; Su Sien Ong; Lie Li; Shuiying Hu; Guoqing Du; Jason A Sprowl; Aksana Vasilyeva; Laura J Janke; Eberhard Schlatter; Taosheng Chen; Giuliano Ciarimboli; Alex Sparreboom
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-06       Impact factor: 11.205

4.  p38α controls erythroblast enucleation and Rb signaling in stress erythropoiesis.

Authors:  Simon M Schultze; Andreas Mairhofer; Dan Li; Jin Cen; Hartmut Beug; Erwin F Wagner; Lijian Hui
Journal:  Cell Res       Date:  2011-09-27       Impact factor: 25.617

5.  A single nucleotide polymorphism in the p27(Kip1) gene is associated with primary patency of lower extremity vein bypass grafts.

Authors:  Michael S Conte; Christopher D Owens; Michael Belkin; Mark A Creager; Karen L Edwards; Warren J Gasper; Richard D Kenagy; Renee C LeBoeuf; Michael Sobel; Alexander Clowes
Journal:  J Vasc Surg       Date:  2013-01-09       Impact factor: 4.268

6.  P21waf1/cip1/sdi1 as a central regulator of inducible smooth muscle actin expression and differentiation of cardiac fibroblasts to myofibroblasts.

Authors:  Sashwati Roy; Savita Khanna; Trenton Rink; Jared Radtke; W Taylor Williams; Sabyasachi Biswas; Rebecca Schnitt; Arthur R Strauch; Chandan K Sen
Journal:  Mol Biol Cell       Date:  2007-09-19       Impact factor: 4.138

7.  CDK14 involvement in proliferation migration and invasion of esophageal cancer.

Authors:  Lingling Chen; Yayun Wang; Wenyan Jiang; Runzhou Ni; Yuchan Wang; Sujie Ni
Journal:  Ann Transl Med       Date:  2019-11

8.  STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells.

Authors:  Pankaj Goyal; Antje Behring; Abhishek Kumar; Wolfgang Siess
Journal:  PLoS One       Date:  2011-01-20       Impact factor: 3.240

9.  Ultrasound triggered image-guided drug delivery to inhibit vascular reconstruction via paclitaxel-loaded microbubbles.

Authors:  Xu Zhu; Jun Guo; Cancan He; Huaxiao Geng; Gengsheng Yu; Jinqing Li; Hairong Zheng; Xiaojuan Ji; Fei Yan
Journal:  Sci Rep       Date:  2016-02-22       Impact factor: 4.379

Review 10.  The Involvement of Ubiquitination Machinery in Cell Cycle Regulation and Cancer Progression.

Authors:  Tingting Zou; Zhenghong Lin
Journal:  Int J Mol Sci       Date:  2021-05-27       Impact factor: 5.923
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