Literature DB >> 12401515

CD40 and its viral mimic, LMP1: similar means to different ends.

Ngan Lam1, Bill Sugden.   

Abstract

CD40 is an important regulator of diverse aspects of the immune response including the T-cell-dependent humoral immune response, the development of antigen-presenting cells (APCs) and inflammation. Latent membrane protein 1 (LMP1), a protein encoded by Epstein-Barr Virus (EBV), appears to mimic CD40 in multiple ways. CD40 and LMP1 bind similar sets of cellular signalling proteins and activate overlapping signalling pathways. Despite many similarities shared between CD40 and LMP1, they also differ substantively. In this review, we will compare and contrast the signalling mediated by CD40 and LMP1. Copyright 2002 Elsevier Science Inc.

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Year:  2003        PMID： 12401515     DOI： 10.1016/s0898-6568(02)00083-9

Source DB:  PubMed          Journal:  Cell Signal        ISSN： 0898-6568            Impact factor:   4.315


  42 in total

1.  Comparative analysis of signal transduction by CD40 and the Epstein-Barr virus oncoprotein LMP1 in vivo.

Authors:  Dimitris Panagopoulos; Panayiotis Victoratos; Maria Alexiou; George Kollias; George Mosialos
Journal:  J Virol       Date:  2004-12       Impact factor: 5.103

2.  Identification and characterization of CCAAT enhancer-binding protein (C/EBP) as a transcriptional activator for Epstein-Barr virus oncogene latent membrane protein 1.

Authors:  Chieko Noda; Takayuki Murata; Teru Kanda; Hironori Yoshiyama; Atsuko Sugimoto; Daisuke Kawashima; Shinichi Saito; Hiroki Isomura; Tatsuya Tsurumi
Journal:  J Biol Chem       Date:  2011-10-19       Impact factor: 5.157

Review 3.  EBV Persistence--Introducing the Virus.

Authors:  David A Thorley-Lawson
Journal:  Curr Top Microbiol Immunol       Date:  2015       Impact factor: 4.291

4.  The Epstein-Barr virus EBNA-LP protein preferentially coactivates EBNA2-mediated stimulation of latent membrane proteins expressed from the viral divergent promoter.

Authors:  Rongsheng Peng; Stephanie C Moses; Jie Tan; Elisabeth Kremmer; Paul D Ling
Journal:  J Virol       Date:  2005-04       Impact factor: 5.103

5.  The Epstein-Barr virus-encoded LMP-1 oncoprotein negatively affects Tyk2 phosphorylation and interferon signaling in human B cells.

Authors:  Timothy R Geiger; Jennifer M Martin
Journal:  J Virol       Date:  2006-09-20       Impact factor: 5.103

6.  Epstein-Barr virus (EBV) latent membrane protein-1 down-regulates tumor necrosis factor-alpha (TNF-alpha) receptor-1 and confers resistance to TNF-alpha-induced apoptosis in T cells: implication for the progression to T-cell lymphoma in EBV-associated hemophagocytic syndrome.

Authors:  Huai-Chia Chuang; Jong-Ding Lay; Shuang-En Chuang; Wen-Chuan Hsieh; Yao Chang; Ih-Jen Su
Journal:  Am J Pathol       Date:  2007-05       Impact factor: 4.307

7.  A membrane leucine heptad contributes to trafficking, signaling, and transformation by latent membrane protein 1.

Authors:  Jisook Lee; Bill Sugden
Journal:  J Virol       Date:  2007-06-20       Impact factor: 5.103

8.  Interleukins, laminin and Epstein - Barr virus latent membrane protein 1 (EBV LMP1) promote metastatic phenotype in nasopharyngeal carcinoma.

Authors:  Michelle M S Chew; Sook-Yee Gan; Alan S B Khoo; Eng-Lai Tan
Journal:  BMC Cancer       Date:  2010-10-22       Impact factor: 4.430

9.  Epstein-Barr virus Latent Membrane Protein 2A (LMP2A)-mediated changes in Fas expression and Fas-dependent apoptosis: Role of Lyn/Syk activation.

Authors:  Ryan Incrocci; Samira Hussain; Amanda Stone; Kathryn Bieging; Lauren A C Alt; Michael J Fay; Michelle Swanson-Mungerson
Journal:  Cell Immunol       Date:  2015-08-04       Impact factor: 4.868

10.  Inhibition of p38 MAP kinase pathway induces apoptosis and prevents Epstein Barr virus reactivation in Raji cells exposed to lytic cycle inducing compounds.

Authors:  Giulia Matusali; Giuseppe Arena; Alessandra De Leo; Livia Di Renzo; Elena Mattia
Journal:  Mol Cancer       Date:  2009-03-09       Impact factor: 27.401
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