| Literature DB >> 12399008 |
Motoi Kobashi1, Yuichi Furudono, Ryuji Matsuo, Takashi Yamamoto.
Abstract
The effects of the intracisternal administration of synthetic orexin-A (3 nmol) on gastric motility were examined in rats. The administration of orexin but not a vehicle induced relaxation of the proximal stomach lasting for more than 30 min. Phasic contractions in the distal stomach were facilitated in response to the administration of orexin but not a vehicle. Facilitation in the distal stomach was not observed in the animals which underwent the sectioning of the bilateral vagi at the subdiaphragmatic level. Relaxation of the proximal stomach was observed in vagotomized animals but the magnitude of relaxation was significantly smaller than that in intact animals. These results suggest that central orexin facilitates distal stomach motility and relaxation of the proximal stomach via vagi. Copyright 2002 Elsevier Science Ireland Ltd.Entities:
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Year: 2002 PMID： 12399008 DOI： 10.1016/s0304-3940(02)00958-8
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046