Literature DB >> 1239837

Effect of peptichemio exposure on DNA synthesis in a mammalian cell system in vitro.

O Djordjević, L Kostić, G Astaldi.   

Abstract

The effect of Peptichemio (PTC) on the survival and DNA synthesis in mouse L-cells was studied. Experimental data show that a typical dose-survival curve is obtained when L-cells are cultivated in the presence of PTC. Exposure of L-cells to various concentrations of PTC caused an inhibition in cellular ability to synthesize DNA which is evidenced by the decreased incorporation of 3H-thymidine. This inhibition is dependent on the concentration of PTC and the time of exposure.

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Year:  1975        PMID: 1239837     DOI: 10.1177/030089167506100507

Source DB:  PubMed          Journal:  Tumori        ISSN: 0300-8916


  1 in total

1.  Increased cancericidal activity of PTT.119, a new synthetic bis-(2-chloroethyl)amino-L-phenylalanine derivative with carrier amino acids. I. In vitro cytotoxicity.

Authors:  M J Yagi; J G Bekesi; M D Daniel; J F Holland; A De Barbieri
Journal:  Cancer Chemother Pharmacol       Date:  1984       Impact factor: 3.333

  1 in total

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