Literature DB >> 12398231

Effect of hypothyroidism on synaptosomal-associated protein of 25 kDa and syntaxin-1 expression in adenohypophyses of rat.

J L Quintanar1, E Salinas.   

Abstract

The aim of this study was to analyze the expression of SNAP-25 and syntaxin-1 in the adenohypophyses of hypothyroid rats. Rats were divided into: 1) controls; 2) thyroidectomized 40 days; and 3) thyroidectomized 40 days with replacement of T4 20 days after surgery. Adenohypophyses were studied by immunohistochemistry and immunoblot analysis using antibodies against SNAP-25, syntaxin-1 and TSH. By immunostaining, SNAP-25 and syntaxin-1 were conspicuous and were localized around cytoplasmic vacuoles of thyroidectomy cells. Immunoblot analysis shows that thyroidectomy increases adenohypophysial SNAP-25 expression and decreases syntaxin-1 levels. T4 administration for 20 days produces a recovery similar to control values. In conclusion, thyroidectomy produces changes in both expression and immunoreactivity of SNAP-25 and syntaxin-1 in adenohypophyses of rats and these effects can be reversed by T4 administration.

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Year:  2002        PMID： 12398231     DOI： 10.1007/BF03345507

Source DB:  PubMed          Journal:  J Endocrinol Invest        ISSN： 0391-4097            Impact factor:   4.256


  23 in total

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