BACKGROUND/AIMS: Purpose of this study is to define the effectiveness of surgical resection of liver metastases from operated breast cancer. METHODOLOGY: Nineteen patients underwent surgical exploration to resect liver metastases from previously operated breast carcinoma. Seventeen patients were resected: 15 patients had unique metastases and were submitted to a wedge liver resection while 2 had multiple lesions; in these cases a V-VI segmentectomy and a right hepatectomy was required. After liver resection 11 patients received chemotherapy, 2 chemotherapy plus hormone therapy, 2 hormone therapy alone and in the remaining 2 no adjuvant treatment was done. RESULTS: Postoperative mortality was nil and morbidity consisted of 1 subphrenic abscess and 1 pleural effusion. Actuarial 5-year survival rate was 46%. Eight patients are still alive, 7 of whom are disease-free. Nine patients died for neoplastic progression. CONCLUSIONS: Surgical resection of liver metastases from breast cancer seems to be able to improve long-term survival in selected patients with unique and isolated lesions especially in association to systemic chemotherapy and hormone therapy.
BACKGROUND/AIMS: Purpose of this study is to define the effectiveness of surgical resection of liver metastases from operated breast cancer. METHODOLOGY: Nineteen patients underwent surgical exploration to resect liver metastases from previously operated breast carcinoma. Seventeen patients were resected: 15 patients had unique metastases and were submitted to a wedge liver resection while 2 had multiple lesions; in these cases a V-VI segmentectomy and a right hepatectomy was required. After liver resection 11 patients received chemotherapy, 2 chemotherapy plus hormone therapy, 2 hormone therapy alone and in the remaining 2 no adjuvant treatment was done. RESULTS: Postoperative mortality was nil and morbidity consisted of 1 subphrenic abscess and 1 pleural effusion. Actuarial 5-year survival rate was 46%. Eight patients are still alive, 7 of whom are disease-free. Nine patients died for neoplastic progression. CONCLUSIONS: Surgical resection of liver metastases from breast cancer seems to be able to improve long-term survival in selected patients with unique and isolated lesions especially in association to systemic chemotherapy and hormone therapy.
Authors: Tobias F Jakobs; Ralf-T Hoffmann; Gabriele Poepperl; Anna Schmitz; Jürgen Lutz; Walter Koch; Klaus Tatsch; Andreas Lubiensky; Maximilian F Reiser; Thomas Helmberger Journal: Eur Radiol Date: 2006-12-06 Impact factor: 5.315
Authors: Maria A Cassera; Chet W Hammill; Michael B Ujiki; Ronald F Wolf; Lee L Swanström; Paul D Hansen Journal: HPB (Oxford) Date: 2011-04 Impact factor: 3.647
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Authors: Y Dittmar; A Altendorf-Hofmann; S Schüle; M Ardelt; O Dirsch; I B Runnebaum; U Settmacher Journal: J Cancer Res Clin Oncol Date: 2013-05-04 Impact factor: 4.553