BACKGROUND: Biochemical markers released after head injury may reflect the degree of brain damage, which is related to subsequent disability. If the serum level of a marker were found to be related to outcome, then earlier identification and intervention would be possible. OBJECTIVE: To investigate the potential of the serum marker S-100B protein to predict the outcome after head injury. METHODS: Blood samples for S-100B concentrations were taken from 148 adults within six hours of a head injury (initial Glasgow coma score 4-15). Patients were recruited from the emergency departments of four hospitals in Greater Manchester, United Kingdom. Outcome was assessed in 119 patients (80%) at one month using the extended Glasgow outcome scale (GOSE). RESULTS: A significant inverse correlation between serum S-100B level and GOSE was found (Spearman's rho = -0.349, p < 0.0001). A serum S-100B concentration of > 0.32 micro g/l predicted severe disability (GOSE < 5) at one month with a sensitivity of 93% (95% confidence interval 68% to 100%), a specificity of 72% (54% to 79%), and a negative predictive value of 99% (93% to 100%). CONCLUSION: Serum S-100B concentration can be used in the emergency department to identify patients with head injury who are most likely to have a poor outcome at one month.
BACKGROUND: Biochemical markers released after head injury may reflect the degree of brain damage, which is related to subsequent disability. If the serum level of a marker were found to be related to outcome, then earlier identification and intervention would be possible. OBJECTIVE: To investigate the potential of the serum marker S-100B protein to predict the outcome after head injury. METHODS: Blood samples for S-100B concentrations were taken from 148 adults within six hours of a head injury (initial Glasgow coma score 4-15). Patients were recruited from the emergency departments of four hospitals in Greater Manchester, United Kingdom. Outcome was assessed in 119 patients (80%) at one month using the extended Glasgow outcome scale (GOSE). RESULTS: A significant inverse correlation between serum S-100B level and GOSE was found (Spearman's rho = -0.349, p < 0.0001). A serum S-100B concentration of > 0.32 micro g/l predicted severe disability (GOSE < 5) at one month with a sensitivity of 93% (95% confidence interval 68% to 100%), a specificity of 72% (54% to 79%), and a negative predictive value of 99% (93% to 100%). CONCLUSION: Serum S-100B concentration can be used in the emergency department to identify patients with head injury who are most likely to have a poor outcome at one month.
Authors: H S Levin; C Boake; J Song; S Mccauley; C Contant; P Diaz-Marchan; S Brundage; H Goodman; K J Kotrla Journal: J Neurotrauma Date: 2001-06 Impact factor: 5.269
Authors: Stefanos Korfias; George Stranjalis; Efstathios Boviatsis; Christina Psachoulia; Gerard Jullien; Barbara Gregson; A David Mendelow; Damianos E Sakas Journal: Intensive Care Med Date: 2006-12-02 Impact factor: 17.440
Authors: Michael V DeFazio; Richard A Rammo; Jaime R Robles; Helen M Bramlett; W Dalton Dietrich; M Ross Bullock Journal: World Neurosurg Date: 2013-01-08 Impact factor: 2.104
Authors: Marek Ma; Christopher J Lindsell; Clark M Rosenberry; George J Shaw; Frank P Zemlan Journal: Am J Emerg Med Date: 2008-09 Impact factor: 2.469
Authors: Kun Zhang; Man Li; Xiao-Chun Peng; Li-Shen Wang; Ai-Ping Dong; Shu-Wei Shen; Rong Wang Journal: Iran J Pharm Res Date: 2015 Impact factor: 1.696