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Literature DB >> 12396101

Brain stem GABA receptor functional regulation during rat liver cell proliferation.

Mangatt P Biju¹, Sulaiman Pyroja, Neelimmathara V Rajeshkumar, Cheramadathikudyil S Paulose.

Abstract

GABAergic alterations in brain stem during compensatory hyperplasia after partial hepatectomy (PH), lead nitrate (LN)-induced direct hyperplasia, and N-nitrosodiethylamine (NDEA)-induced neoplasia in liver were investigated. GABA content decreased in brain stem of PH- and NDEA-treated rats while it increased in LN-treated rats. GABA(A) receptor number and affinity in brain stem membrane preparations of rats showed a significant decrease in PH- and NDEA-treated rats. The GABA(B) receptor number increased in PH- and NDEA-treated rats with an increase in affinity. The results of the present study indicate that liver cell proliferation is influencing the brain stem GABAergic neurotransmission and these changes regulate the hepatic proliferation through the sympathetic stimulation.

Entities: Chemical Disease Species

Mesh：

Substances：
Receptors, GABA
Baclofen

Year: 2002 PMID： 12396101 DOI： 10.1023/a:1020391514995

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

30 in total

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Authors: Y Kubo; M Yasunaga; M Masuhara; S Terai; T Nakamura; K Okita
Journal: Hepatology Date: 1996-01 Impact factor: 17.425

Brain stem GABA receptor functional regulation during rat liver cell proliferation.

Review 1. The neurobiology of hepatic encephalopathy.

2. GABA receptor binding with [3H]GABA and [3H](+)bicuculline-methiodide: an improved method.

3. Endogenous GABA acts on GABAB receptors in nucleus tractus solitarius to increase blood pressure.

4. The role of brain acetylcholine in GABAA receptor antagonist-induced blood-pressure changes in rat.

5. Hypothalamic and medullary GABAA and GABAB-ergic systems differently regulate sympathetic and cardiovascular systems.

6. Central thyrotropin-releasing hormone stimulates hepatic DNA synthesis in rats.

7. Effects of central GABA receptors activation on catecholamine secretion in rats.

8. Hepatocyte proliferation induced in rats by lead nitrate is suppressed by several tumor necrosis factor alpha inhibitors.

9. Glucose modulates gamma-aminobutyric acid release from the pancreatic beta TC6 cell line.

10. Inhibition of GABAB receptor binding by guanyl nucleotides.

1. Enhanced 5-HT(2A) receptor status in the hypothalamus and corpus striatum of ethanol-treated rats.

2. Decreased hepatic 5-HT1A receptors during liver regeneration and neoplasia in rats.

3. Valerian inhibits rat hepatocarcinogenesis by activating GABA(A) receptor-mediated signaling.

4. Therapeutic ultrasound in fracture healing: The mechanism of osteoinduction.