Literature DB >> 12395101

Brain-derived neurotrophic factor induces NMDA receptor 1 phosphorylation in rat spinal cord.

Sarah E Slack1, Stephen W N Thompson.   

Abstract

The NMDA receptor and the neurotrophin brain-derived neurotrophic factor, BDNF, are involved in central sensitisation and synaptic plasticity in the spinal cord. Recent evidence suggests that BDNF modulates NMDA responses, by a yet unknown mechanism. The phosphorylation of the NMDA subunit 1 following BDNF exposure has been investigated in the neonatal rat spinal cord. Western blotting revealed that BDNF administered to isolated cords for 20 minutes significantly elevated phospho-NR1 levels. Immunohistochemical analysis localised this increase to functionally appropriate regions of the dorsal horn. Pre-incubation with trkB-IgG (BDNF sequestering molecule) abolished this NR1 phosphorylation. We suggest that BDNF modulates synaptic activity within the spinal cord via NR1 phosphorylation.

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Year:  2002        PMID： 12395101     DOI： 10.1097/00001756-200210280-00027

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  9 in total

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Review 8.  Interplay of BDNF and GDNF in the Mature Spinal Somatosensory System and Its Potential Therapeutic Relevance.

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