PURPOSE: To assess the occurrence of two mutations associated with susceptibility to aminoglycoside ototoxicity. METHODS: Genetic analysis of anonymized, residual diagnostic specimens. RESULTS: One occurrence of the A1555G mutation and seven occurrences of the 961delT + C(n) nucleotide change were found. Two previously unreported sequence changes, T961G and 956-960insC, were also found in six and five specimens, respectively. CONCLUSIONS: Genetic susceptibility to aminoglycoside ototoxicity may be more common than previously suspected. Further study of the 961delT + C(n) mutation is recommended to confirm its role in aminoglycoside ototoxicity and assess penetrance and variability with and without exposure to aminoglycoside antibiotics.
PURPOSE: To assess the occurrence of two mutations associated with susceptibility to aminoglycoside ototoxicity. METHODS: Genetic analysis of anonymized, residual diagnostic specimens. RESULTS: One occurrence of the A1555G mutation and seven occurrences of the 961delT + C(n) nucleotide change were found. Two previously unreported sequence changes, T961G and 956-960insC, were also found in six and five specimens, respectively. CONCLUSIONS: Genetic susceptibility to aminoglycoside ototoxicity may be more common than previously suspected. Further study of the 961delT + C(n) mutation is recommended to confirm its role in aminoglycoside ototoxicity and assess penetrance and variability with and without exposure to aminoglycoside antibiotics.
Authors: K Allegaert; I Scheers; E Adams; G Brajanoski; V Cossey; B J Anderson Journal: Antimicrob Agents Chemother Date: 2008-03-31 Impact factor: 5.191
Authors: Dawn Konrad-Martin; Gayla L Poling; Angela C Garinis; Candice E Ortiz; Jennifer Hopper; Keri O'Connell Bennett; Marilyn F Dille Journal: Int J Audiol Date: 2017-11-20 Impact factor: 2.117