| Literature DB >> 12393381 |
Christophe Roumier1, Virginie Eclache, Michelle Imbert, Frederic Davi, Elizabeth MacIntyre, Richard Garand, Pascaline Talmant, Pascale Lepelley, Jean Luc Lai, Olivier Casasnovas, Marc Maynadie, Francine Mugneret, Chrystele Bilhou-Naberra, Francoise Valensi, Isabelle Radford, Marie Joelle Mozziconacci, Christine Arnoulet, Eliane Duchayne, Nicole Dastugue, Pascale Cornillet, Sylvie Daliphard, Francine Garnache, Najiba Boudjerra, Helene Jouault, Odile Fenneteau, Béatrice Pedron, Roland Berger, Georges Flandrin, Pierre Fenaux, Claude Preudhomme.
Abstract
Mutations of the AML1 gene are frequent molecular abnormalities in minimally differentiated acute myeloblastic leukemia (M0 AML), a rare type of AML. In this retrospective multicenter study, morphologic, immunophenotypical, cytogenetic, and molecular features of 59 de novo M0 AML cases were analyzed and correlated to AML1 mutations. Point mutations of AML1 gene were observed in 16 cases (27%). They were correlated with higher white blood cell (WBC) count (P =.001), greater marrow blast involvement (P =.03), higher incidence of immunoglobulin H/T-cell receptor (IgH/TCR) gene rearrangement (P <.0001), and with a borderline significant lower incidence of complex karyotypes. In the 59 patients, FLT3 mutations were the only significant prognostic factors associated with short survival.Entities:
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Year: 2002 PMID： 12393381 DOI： 10.1182/blood-2002-05-1474
Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113