Literature DB >> 12393237

Expression of 5-HT(2A) receptor mRNA in some nuclei of brain stem enhanced in monoarthritic rats.

Hong Xie1, Fei Ma, Yu-Qiu Zhang, Xiu Gao, Gen-Cheng Wu.   

Abstract

The present study was designed to investigate the expression of 5-hydroxytryptamine (5-HT) (2A) receptor mRNA in the nucleus of raphe magnus (NRM), ventrolateral periaqueductal gray (vlPAG) and dorsal raphe nucleus (DRN) in a monoarthritic rat model using an in situ hybridization technique. 5-HT(2A) receptor mRNA was expressed with low to moderate levels in NRM, vlPAG and DRN. After complete Freund's adjuvant (CFA)-induced monoarthritis, a significant increase in 5-HT(2A) receptor mRNA expression was observed in bilateral NRM, vlPAG and DRN, and the change lasted, at least, for 2 weeks. This result indicates that the synthesis of 5-HT(2A) receptor is enhanced in bilateral NRM, vlPAG and DRN of monoarthritic rats, suggesting that 5-HT(2A) receptor is involved in the central regulation of pain transmission following CFA-induced chronic inflammation.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12393237     DOI： 10.1016/s0006-8993(02)03347-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

Review 1.  Mechanisms, impact and management of pain in rheumatoid arthritis.

Authors:  David A Walsh; Daniel F McWilliams
Journal:  Nat Rev Rheumatol       Date:  2014-05-27       Impact factor: 20.543

2.  5-HT₂A receptor inactivation potentiates the acute antidepressant-like activity of escitalopram: involvement of the noradrenergic system.

Authors:  G Quesseveur; C Repérant; D J David; A M Gardier; C Sanchez; B P Guiard
Journal:  Exp Brain Res       Date:  2013-02-15       Impact factor: 1.972

3.  Chronic inflammatory pain prevents tolerance to the antinociceptive effect of morphine microinjected into the ventrolateral periaqueductal gray of the rat.

Authors:  Melissa L Mehalick; Susan L Ingram; Sue A Aicher; Michael M Morgan
Journal:  J Pain       Date:  2013-10-22       Impact factor: 5.820

Review 4.  Central serotonin-2A (5-HT2A) receptor dysfunction in depression and epilepsy: the missing link?

Authors:  Bruno P Guiard; Giuseppe Di Giovanni
Journal:  Front Pharmacol       Date:  2015-03-17       Impact factor: 5.810

5.  The 5-HT2A receptor potassium-chloride cotransporter 2 signaling pathway in a rat incision pain model.

Authors:  Rong Dong; Buwei Yu; Lijiao Chen; Weifeng Yu
Journal:  Exp Ther Med       Date:  2016-10-14       Impact factor: 2.447

6.  Spinal 5-HT2A receptor is involved in electroacupuncture inhibition of chronic pain.

Authors:  Xiao-Cui Yuan; Yu-Ying Wang; Li-Xia Tian; Xiang-Ji Yan; Yi-Xiao Guo; Yu-Long Zhao; Sani S Baba; Hong Jia; Hui-Sheng Wang; Man Li; Fu-Quan Huo
Journal:  Mol Pain       Date:  2022 Jan-Dec       Impact factor: 3.395

7.  Postnatal changes in the expressions of serotonin 1A, 1B, and 2A receptors in ten brain stem nuclei of the rat: implication for a sensitive period.

Authors:  Q Liu; M T T Wong-Riley
Journal:  Neuroscience       Date:  2009-10-02       Impact factor: 3.708
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.