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Literature DB >> 1239274

An electrophoretic study of the distribution and properties of human hexokinases.

Abstract

An electrophoretic system which gives a clear separation of human hexokinases HK1, HK2 and HK3 is described. The distribution of the hexokinase isozymes in various human tissues, both adult and fetal, is reported. Some properties of the isozymes were investigated. HK2 was found to be more thermolabile than HK1, and there was also a small but significant difference in molecular size. Unlike HK3, HK1 and HK2 are not inhibited by high glucose concentrations. Screening of red cell lysates from 800 unrelated European individuals revealed no genetic variants of HK1 and HK2. However, in view of their difference in properties, it seems probable that the HK1 and HK2 isozymes are determined by separate gene loci.

Entities: Chemical Gene Species

Mesh：

Substances：
Isoenzymes
Hexokinase

Year: 1975 PMID： 1239274 DOI： 10.1007/bf00484416

Source DB: PubMed Journal: Biochem Genet ISSN： 0006-2928 Impact factor: 1.890

20 in total

1. LACTIC DEHYDROGENASE: GENETIC CONTROL IN MAN.

Authors: W E NANCE; A CLAFLIN; O SMITHIES
Journal: Science Date: 1963-11-22 Impact factor: 47.728

2. KINETIC AND ELECTROPHORETIC EVIDENCE FOR MULTIPLE FORMS OF GLUCOSE-ATP PHOSPHOTRANSFERASE ACTIVITY FROM HUMAN CELL CULTURES AND RAT LIVER.

Authors: H M KATZEN; D D SODERMAN; H M NITOWSKY
Journal: Biochem Biophys Res Commun Date: 1965-04-23 Impact factor: 3.575

3. An examination of the age-related patterns of decay of acid phosphatase (ACP1) in human red cells from individuals of different phenotypes.

Authors: P A Rogers; R A Fisher; W Putt
Journal: Biochem Genet Date: 1978-08 Impact factor: 1.890

4. An investigation of the products of 53 gene loci in three species of wild Canidae: Canis lupus, Canis latrans, and Canis familiaris.

Authors: R A Fisher; W Putt; E Hackel
Journal: Biochem Genet Date: 1976-12 Impact factor: 1.890

5. Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients.

Authors: H Vestergaard; C Bjørbaek; T Hansen; F S Larsen; D K Granner; O Pedersen
Journal: J Clin Invest Date: 1995-12 Impact factor: 14.808

Review 6. Pathogenesis of insulin resistance in skeletal muscle.

Authors: Muhammad A Abdul-Ghani; Ralph A DeFronzo
Journal: J Biomed Biotechnol Date: 2010-04-26

6 in total

An electrophoretic study of the distribution and properties of human hexokinases.

1. LACTIC DEHYDROGENASE: GENETIC CONTROL IN MAN.

2. KINETIC AND ELECTROPHORETIC EVIDENCE FOR MULTIPLE FORMS OF GLUCOSE-ATP PHOSPHOTRANSFERASE ACTIVITY FROM HUMAN CELL CULTURES AND RAT LIVER.

3. Hexokinase isozymes in human erythrocytes.

4. Normal and variant isoenzymes of human blood cell hexokinase and the isoenzyme patterns in hemolytic anemia.

5. Thermostability studies on the isozymes of human phosphoglucomutase.

6. Molecular size estimates of human peptidases determined by separate gene loci.

7. Multiple forms of hexokinase in the rat: tissue distribution, age dependency, and properties.

8. Multiple hexokinases of rat tissues. Purification and comparison of soluble forms.

9. Genetically determined polymorphism of a form of hexokinase, HK III, found in human leucocytes.

10. Hexokinase isoenzymes in human erythrocytes.

1. The genetics of hexokinase in a mosquito, Culex pipiens.

Review 2. A survey on the formation and localization of secondary isozymes in mammalia.

3. An examination of the age-related patterns of decay of acid phosphatase (ACP1) in human red cells from individuals of different phenotypes.

4. An investigation of the products of 53 gene loci in three species of wild Canidae: Canis lupus, Canis latrans, and Canis familiaris.

5. Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients.

Review 6. Pathogenesis of insulin resistance in skeletal muscle.