Literature DB >> 12392737

Synthesis and evaluation of water-soluble paclitaxel prodrugs.

Xia Feng1, Ying-Jin Yuan, Jin-Chuan Wu.   

Abstract

A series of water-soluble 2'-paclitaxel prodrugs were synthesized by attaching paclitaxel to polyethylene glycol (PEG) through amino acid spacers. The prodrugs showed highly improved water solubility, enhanced in vitro cytotoxicity and in vivo antitumor activity compared with the native drug, paclitaxel.

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Year:  2002        PMID： 12392737     DOI： 10.1016/s0960-894x(02)00694-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  2'-Behenoyl-paclitaxel conjugate containing lipid nanoparticles for the treatment of metastatic breast cancer.

Authors:  Ping Ma; S Rahima Benhabbour; Lan Feng; Russell J Mumper
Journal:  Cancer Lett       Date:  2012-08-16       Impact factor: 8.679

2.  Kinetics of paclitaxel 2'-N-methylpyridinium mesylate decomposition.

Authors:  Jaber G Qasem; Paul M Bummer; George A Digenis
Journal:  AAPS PharmSciTech       Date:  2003       Impact factor: 3.246

3.  Delivery of baicalein and paclitaxel using self-assembled nanoparticles: synergistic antitumor effect in vitro and in vivo.

Authors:  Wei Wang; Mei Xi; Xuezhong Duan; Yong Wang; Fansheng Kong
Journal:  Int J Nanomedicine       Date:  2015-05-22

4.  Antitumor effect of iRGD-modified liposomes containing conjugated linoleic acid-paclitaxel (CLA-PTX) on B16-F10 melanoma.

Authors:  Ruo Du; Ting Zhong; Wei-Qiang Zhang; Ping Song; Wen-Ding Song; Yang Zhao; Chao Wang; Yi-Qun Tang; Xuan Zhang; Qiang Zhang
Journal:  Int J Nanomedicine       Date:  2014-06-24

5.  Combination Therapy of Lung Cancer Using Layer-by-Layer Cisplatin Prodrug and Curcumin Co-Encapsulated Nanomedicine.

Authors:  Yuan Hong; Shaomin Che; Beina Hui; Xiaoli Wang; Xiaozhi Zhang; Hailin Ma
Journal:  Drug Des Devel Ther       Date:  2020-06-09       Impact factor: 4.162

6.  Synthesis and Feasibility Evaluation of a new Trastuzumab Conjugate Integrated with Paclitaxel and 89Zr for Theranostic Application Against HER2-Expressing Breast Cancers.

Authors:  Joo Hee Jang; Sang Jin Han; Jung Young Kim; Kwang Il Kim; Kyo Chul Lee; Chi Soo Kang
Journal:  ChemistryOpen       Date:  2019-04-08       Impact factor: 2.911

Review 7.  Prodrug Strategies for Paclitaxel.

Authors:  Ziyuan Meng; Quanxia Lv; Jun Lu; Houzong Yao; Xiaoqing Lv; Feng Jiang; Aiping Lu; Ge Zhang
Journal:  Int J Mol Sci       Date:  2016-05-23       Impact factor: 5.923

Review 8.  Design, synthesis and applications of hyaluronic acid-paclitaxel bioconjugates.

Authors:  Francesca Leonelli; Angela La Bella; Luisa Maria Migneco; Rinaldo Marini Bettolo
Journal:  Molecules       Date:  2008-02-12       Impact factor: 4.411
  8 in total

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