Literature DB >> 12392724

Effective artificial proteases synthesized by covering silica gel with aldehyde and various other organic groups.

Hyunsook Kim1, Myoung-soon Kim, Hyesun Paik, Yeon-Sook Chung, In Seok Hong, Junghun Suh.   

Abstract

Organic artificial proteases with broad substrate specificity were synthesized by covering the surface of silica gel with aldehyde and the functional groups present in amino acids. The artificial proteases hydrolyzed ovalbumin, albumin, hemoglobin, gamma-globulin with half-lives as short as 50 min at 25 degrees C or 7 min at 50 degrees C.

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Year:  2002        PMID: 12392724     DOI: 10.1016/s0960-894x(02)00724-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Soluble artificial metalloproteases with broad substrate selectivity, high reactivity, and high thermal and chemical stabilities.

Authors:  Min Gyum Kim; Sang Ho Yoo; Woo Suk Chei; Tae Yeon Lee; Hye Mi Kim; Junghun Suh
Journal:  J Biol Inorg Chem       Date:  2010-04-28       Impact factor: 3.358

2.  MOFzyme: Intrinsic protease-like activity of Cu-MOF.

Authors:  Bin Li; Daomei Chen; Jiaqiang Wang; Zhiying Yan; Liang Jiang; Jiao He; Zhongrui Luo; Jinping Zhang; Fagui Yuan
Journal:  Sci Rep       Date:  2014-10-24       Impact factor: 4.379

  2 in total

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