Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 DNA strand exchange stimulated by spontaneous complex formation with cationic comb-type copolymer.

Literature DB >> 12392411

DNA strand exchange stimulated by spontaneous complex formation with cationic comb-type copolymer.

Won Jong Kim¹, Toshihiro Akaike, Atsushi Maruyama.

Abstract

Cationic comb-type copolymers (CCCs) composed of a polycation backbone and water-soluble side chains accelerate by 4-5 orders the DNA strand exchange reaction (SER) between double helical DNA and its homologous single-strand DNA. The accelerating effect is considered due to alleviation of counterion association during transitional intermediate formation in sequential displacement pathway. CCCs stabilize not only matured hybrids but also the nucleation complex to accelerate hybridization.

Entities: Chemical

Mesh：

Substances：

Year: 2002 PMID： 12392411 DOI： 10.1021/ja0272080

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

Keyword Cloud
Cited

8 in total

1. Liquid crystal self-assembly of random-sequence DNA oligomers.

Authors: Tommaso Bellini; Giuliano Zanchetta; Tommaso P Fraccia; Roberto Cerbino; Ethan Tsai; Gregory P Smith; Mark J Moran; David M Walba; Noel A Clark
Journal: Proc Natl Acad Sci U S A Date: 2012-01-10 Impact factor: 11.205

2. Invader LNA: efficient targeting of short double stranded DNA.

Authors: Sujay P Sau; T Santhosh Kumar; Patrick J Hrdlicka
Journal: Org Biomol Chem Date: 2010-03-04 Impact factor: 3.876

3. Easily denaturing nucleic acids derived from intercalating nucleic acids: thermal stability studies, dual duplex invasion and inhibition of transcription start.

Authors: Vyacheslav V Filichev; Birte Vester; Lykke H Hansen; Erik B Pedersen
Journal: Nucleic Acids Res Date: 2005-12-23 Impact factor: 16.971

DNA strand exchange stimulated by spontaneous complex formation with cationic comb-type copolymer.

1. Liquid crystal self-assembly of random-sequence DNA oligomers.

2. Invader LNA: efficient targeting of short double stranded DNA.

3. Easily denaturing nucleic acids derived from intercalating nucleic acids: thermal stability studies, dual duplex invasion and inhibition of transcription start.

4. Cooperative enhancement of deoxyribozyme activity by chemical modification and added cationic copolymer.

5. DNA Self-assembly Catalyzed by Artificial Agents.

6. Accelerating DNA-Based Computing on a Supramolecular Polymer.

7. Equilibrious strand exchange promoted by DNA conformational switching.

8. Activation of DNA strand exchange by cationic comb-type copolymers: effect of cationic moieties of the copolymers.