Literature DB >> 12391597

Role of mitochondrial dysfunction in Alzheimer's disease.

Rudy Castellani1, Keisuke Hirai, Gjumrakch Aliev, Kelly L Drew, Akihiko Nunomura, Atsushi Takeda, Adam D Cash, Mark E Obrenovich, George Perry, Mark A Smith.   

Abstract

Abnormalities in mitochondrial function relate to the spectrum of pathological changes seen in Alzheimer's disease. Here we review the causes and consequences of mitochondrial disturbances in Alzheimer's disease as well as how this information might impact on therapeutic approaches to this disease. Copyright 2002 Wiley-Liss, Inc.

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Year:  2002        PMID： 12391597     DOI： 10.1002/jnr.10389

Source DB:  PubMed          Journal:  J Neurosci Res        ISSN： 0360-4012            Impact factor:   4.164


  103 in total

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2.  Antioxidant and neuroprotective effects of Scrophularia striata extract against oxidative stress-induced neurotoxicity.

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Review 5.  Possibility of selection against mtDNA mutations in tumors.

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Review 7.  Oxidative stress signaling in Alzheimer's disease.

Authors:  B Su; X Wang; A Nunomura; P I Moreira; H-gon Lee; G Perry; M A Smith; X Zhu
Journal:  Curr Alzheimer Res       Date:  2008-12       Impact factor: 3.498

Review 8.  A novel high-throughput assay for respiration in isolated brain microvessels reveals impaired mitochondrial function in the aged mice.

Authors:  Venkata N Sure; Siva S V P Sakamuri; Jared A Sperling; Wesley R Evans; Ivan Merdzo; Ricardo Mostany; Walter L Murfee; David W Busija; Prasad V G Katakam
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9.  Memantine prevents sensitivity to excitotoxic cell death of rat cortical neurons expressing human truncated tau protein.

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10.  Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: implications for early mitochondrial dysfunction and oxidative damage.

Authors:  Maria Manczak; Byung S Park; Youngsin Jung; P Hemachandra Reddy
Journal:  Neuromolecular Med       Date:  2004       Impact factor: 3.843
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