Literature DB >> 12391560

Hepatoprotective and free radical scavenging activities of prenylflavonoids, coumarin, and stilbene from Morus alba.

Hyuncheol Oh1, Eun-Kyung Ko, Jung-Yang Jun, Myung-Hoon Oh, Sung-Uk Park, Ki-Hong Kang, Ho-Sub Lee, Youn-Chul Kim.   

Abstract

Chemical investigation of the EtOH extract of Morus alba L. (Moraceae), as guided by free radical scavenging activity, furnished 5,7-dihydroxycoumarin 7-methyl ether (1), two prenylflavones, cudraflavone B (2) and cudraflavone C (3), and oxyresveratrol (4). Compounds 1 and 4 showed superoxide scavenging effects with the IC(50) values of 19.1 +/- 3.6 and 3.81 +/- 0.5 microM, respectively. Compound 4 exhibited a DPPH free radical scavenging effect (IC(50) = 23.4 +/- 1.5 microM). Compounds 2 and 4 showed hepatoprotective effects with EC(50) values of 10.3 +/- 0.42 and 32.3 +/- 2.62 micro, respectively, on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells.

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Year:  2002        PMID： 12391560     DOI： 10.1055/s-2002-34930

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  11 in total

1.  Consumption of polyphenol-rich Morus alba leaves extract attenuates early diabetic retinopathy: the underlying mechanism.

Authors:  Ayman M Mahmoud; Sanaa M Abd El-Twab; Eman S Abdel-Reheim
Journal:  Eur J Nutr       Date:  2016-04-08       Impact factor: 5.614

2.  Effect of Morus alba L. (mulberry) leaves on anxiety in mice.

Authors:  A V Yadav; L A Kawale; V S Nade
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3.  Antihyperglycemic, antioxidant and antiglycation activities of mulberry leaf extract in streptozotocin-induced chronic diabetic rats.

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4.  Morus alba and active compound oxyresveratrol exert anti-inflammatory activity via inhibition of leukocyte migration involving MEK/ERK signaling.

Authors:  Yi-Ching Chen; Yin-Jing Tien; Chun-Houh Chen; Francesca N Beltran; Evangeline C Amor; Ran-Juh Wang; Den-Jen Wu; Clément Mettling; Yea-Lih Lin; Wen-Chin Yang
Journal:  BMC Complement Altern Med       Date:  2013-02-23       Impact factor: 3.659

5.  Evaluation of cytotoxicity and genotoxicity of some Philippine medicinal plants.

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Journal:  Pharmacogn Mag       Date:  2011-04       Impact factor: 1.085

6.  Anti-dopaminergic effect of the methanolic extract of Morus alba L. leaves.

Authors:  Adhikrao V Yadav; Vandana S Nade
Journal:  Indian J Pharmacol       Date:  2008-10       Impact factor: 1.200

7.  Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1/S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response.

Authors:  Peter Kollar; Tomáš Bárta; Jan Hošek; Karel Souček; Veronika Müller Závalová; Shushan Artinian; Rabih Talhouk; Karel Smejkal; Pavel Suchý; Aleš Hampl
Journal:  Evid Based Complement Alternat Med       Date:  2013-05-20       Impact factor: 2.629

8.  The cardioprotective power of leaves.

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Journal:  Arch Med Sci       Date:  2015-08-11       Impact factor: 3.318

9.  Analysis of Functional Constituents in Mulberry (Morus alba L.) Twigs by Different Cultivars, Producing Areas, and Heat Processings.

Authors:  Sang Won Choi; Yeon Jeong Jang; Yu Jin Lee; Hyun Hee Leem; Eun Ok Kim
Journal:  Prev Nutr Food Sci       Date:  2013-12

10.  Isocudraxanthone K induces growth inhibition and apoptosis in oral cancer cells via hypoxia inducible factor-1α.

Authors:  Mee-Ran Shin; Hwa-Jeong Lee; Soo-Kyung Kang; Q-Schick Auh; Young-Man Lee; Youn-Chul Kim; Eun-Cheol Kim
Journal:  Biomed Res Int       Date:  2014-07-03       Impact factor: 3.411
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