Literature DB >> 12391556

An isorhapontigenin tetramer and a novel stilbene dimer from Gnetum hainanense.

Kai-Sheng Huang1, Shan Zhou, Mao Lin, Ying-Hong Wang.   

Abstract

The first isorhapontigenin tetramer, gnetuhainin R (1) and a novel dimeric stilbene, gnetuhainin S (2) were isolated from the lianas of Gnetum hainanense. Their structures were elucidated on the basis of spectroscopic and chemical evidence, especially 2D NMR analysis. The structure of 2 was further supported by X-ray crystallographic analysis. The anti-inflammatory activity of 1 has been tested, and it showed potent activity of histamine receptor antagonism.

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Year:  2002        PMID： 12391556     DOI： 10.1055/s-2002-34951

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  5 in total

1.  The Chinese herb isolate isorhapontigenin induces apoptosis in human cancer cells by down-regulating overexpression of antiapoptotic protein XIAP.

Authors:  Yong Fang; Yonghui Yu; Qi Hou; Xiao Zheng; Min Zhang; Dongyun Zhang; Jingxia Li; Xue-Ru Wu; Chuanshu Huang
Journal:  J Biol Chem       Date:  2012-08-15       Impact factor: 5.157

2.  Cyclin d1 downregulation contributes to anticancer effect of isorhapontigenin on human bladder cancer cells.

Authors:  Yong Fang; Zipeng Cao; Qi Hou; Chen Ma; Chunsuo Yao; Jingxia Li; Xue-Ru Wu; Chuanshu Huang
Journal:  Mol Cancer Ther       Date:  2013-05-30       Impact factor: 6.261

3.  Induction of miR-137 by Isorhapontigenin (ISO) Directly Targets Sp1 Protein Translation and Mediates Its Anticancer Activity Both In Vitro and In Vivo.

Authors:  Xingruo Zeng; Zhou Xu; Jiayan Gu; Haishan Huang; Guangxun Gao; Xiaoru Zhang; Jingxia Li; Honglei Jin; Guosong Jiang; Hong Sun; Chuanshu Huang
Journal:  Mol Cancer Ther       Date:  2016-02-01       Impact factor: 6.261

4.  Isorhapontigenin (ISO) inhibited cell transformation by inducing G0/G1 phase arrest via increasing MKP-1 mRNA Stability.

Authors:  Guangxun Gao; Liang Chen; Jingxia Li; Dongyun Zhang; Yong Fang; Haishan Huang; Xiequn Chen; Chuanshu Huang
Journal:  Oncotarget       Date:  2014-05-15

5.  Induction of RAC1 protein translation and MKK7/JNK-dependent autophagy through dicer/miR-145/SOX2/miR-365a axis contributes to isorhapontigenin (ISO) inhibition of human bladder cancer invasion.

Authors:  Xiaohui Hua; Daimin Xiang; Mengxin Guo; Xiaohui Qian; Ruifan Chen; Tengda Li; Zhongxian Tian; Jiheng Xu; Chao Huang; Qipeng Xie; Chuanshu Huang
Journal:  Cell Death Dis       Date:  2022-08-31       Impact factor: 9.685
  5 in total

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