| Literature DB >> 12390543 |
J D Lifson1, M Piatak, J L Rossio, J Bess, E Chertova, D Schneider, R Kiser, V Coalter, B Poore, R Imming, R C Desrosiers, L E Henderson, L O Arthur.
Abstract
A novel type of whole inactivated simian immunodeficiency virus (SIV) virion vaccine immunogen with functional envelope glycoproteins was evaluated, without adjuvant, in rhesus macaques. Immunogens included purified inactivated virions of SIVmac239, a designed mutant of SIVmac239 with gp120 carbohydrate attachment sites deleted (SIVmac239 g4,5), and SIVmneE11S. The vaccines were noninfectious, safe, and immunogenic, inducing antibody responses and cellular responses, including responses by CD8+ lymphocytes. Interpretation of protective efficacy following intrarectal challenge was complicated by incomplete take of the challenge in some SIV naïve controls.Entities:
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Year: 2002 PMID： 12390543 DOI： 10.1034/j.1600-0684.2002.02007.x
Source DB: PubMed Journal: J Med Primatol ISSN： 0047-2565 Impact factor: 0.667