Mary S Hayney1, Jessica M Buck. 1. School of Pharmacy, University of Wisconsin, Madison 53705-2222, USA. mshayney@pharmacy.wisc.edu
Abstract
STUDY OBJECTIVE: To measure age- or sex-related changes in cytochrome P450 (CYP) activity secondary to influenza vaccination. DESIGN: Open-label, single-dose study. SETTING: General clinical research center at a university hospital. SUBJECTS: Fifteen healthy volunteers aged 22-51 years. INTERVENTION: Each subject was given an erythromycin breath test (ERMBT) to measure CYP3A4 activity before influenza immunization and again on day 7 after immunization. Blood was drawn before immunization and on day 28 after immunization to measure influenza antibody concentrations. MEASUREMENTS AND MAIN RESULTS: Age of subject and change in ERMBT results after influenza immunization were correlated (correlation coefficient -0.624, p < 0.015). However, no correlations could be made between antibody concentrations after influenza immunization or change in antibody concentrations from baseline and age. CONCLUSION: Decreases in CYP3A4 activity after influenza immunization are associated with increasing age. The decreases in CYP3A4 activity, however, are not associated with influenza antibody concentrations. This study bears repeating in an older cohort since the study sample did not include elderly individuals.
STUDY OBJECTIVE: To measure age- or sex-related changes in cytochrome P450 (CYP) activity secondary to influenza vaccination. DESIGN: Open-label, single-dose study. SETTING: General clinical research center at a university hospital. SUBJECTS: Fifteen healthy volunteers aged 22-51 years. INTERVENTION: Each subject was given an erythromycin breath test (ERMBT) to measure CYP3A4 activity before influenza immunization and again on day 7 after immunization. Blood was drawn before immunization and on day 28 after immunization to measure influenza antibody concentrations. MEASUREMENTS AND MAIN RESULTS: Age of subject and change in ERMBT results after influenza immunization were correlated (correlation coefficient -0.624, p < 0.015). However, no correlations could be made between antibody concentrations after influenza immunization or change in antibody concentrations from baseline and age. CONCLUSION: Decreases in CYP3A4 activity after influenza immunization are associated with increasing age. The decreases in CYP3A4 activity, however, are not associated with influenza antibody concentrations. This study bears repeating in an older cohort since the study sample did not include elderly individuals.