Literature DB >> 12388783

A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses.

Kazuhiko Yamaguchi1, Miki Tanaka, Akira Mizoguchi, Yoshihiro Hirata, Hiroyoshi Ishizaki, Kumi Kaneko, Jun Miyoshi, Yoshimi Takai.   

Abstract

The Rab3 GDP/GTP exchange protein (Rab3 GEP) activates the Rab3 small GTP-binding protein (G protein) family, including Rab3A that is an important member controlling synaptic vesicle trafficking. Here, we examined the role of Rab3 GEP in regulating neurotransmitter release in autapses of mouse hippocampal neurons in culture. The release probability was markedly reduced in Rab3 GEP-/- neurons, whereas the readily releasable pool size was not different between WT and Rab3 GEP-/- neurons, indicating that Rab3 GEP up-regulates a postdocking step of synaptic exocytosis. Because Rab3A reportedly down-regulates Ca(2+)-triggered fusion of synaptic vesicles, these results provide evidence for a role of Rab3 GEP in the postdocking process distinct from Rab3A activation.

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Year:  2002        PMID： 12388783      PMCID： PMC137918          DOI： 10.1073/pnas.212511399

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  37 in total

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Journal:  Nat Rev Mol Cell Biol       Date:  2001-02       Impact factor: 94.444

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Review 6.  Short-term synaptic plasticity.

Authors:  Robert S Zucker; Wade G Regehr
Journal:  Annu Rev Physiol       Date:  2002       Impact factor: 19.318

7.  Synaptotagmin I functions as a calcium regulator of release probability.

Authors:  R Fernández-Chacón; A Königstorfer; S H Gerber; J García; M F Matos; C F Stevens; N Brose; J Rizo; C Rosenmund; T C Südhof
Journal:  Nature       Date:  2001-03-01       Impact factor: 49.962

8.  Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

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Journal:  J Cell Biol       Date:  2002-02-04       Impact factor: 10.539
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  19 in total

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2.  Regulation of apoptosis and caspase-8 expression in neuroblastoma cells by isoforms of the IG20 gene.

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4.  Rab3 GTPase-activating protein regulates synaptic transmission and plasticity through the inactivation of Rab3.

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Journal:  Proc Natl Acad Sci U S A       Date:  2006-06-16       Impact factor: 11.205

5.  Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans.

Authors:  Timothy R Mahoney; Qiang Liu; Takashi Itoh; Shuo Luo; Gayla Hadwiger; Rose Vincent; Zhao-Wen Wang; Mitsunori Fukuda; Michael L Nonet
Journal:  Mol Biol Cell       Date:  2006-03-29       Impact factor: 4.138

6.  Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression.

Authors:  Chee Yeun Chung; James B Koprich; Penelope J Hallett; Ole Isacson
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-10       Impact factor: 11.205

7.  MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon tumor necrosis factor-alpha treatment.

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Journal:  J Biol Chem       Date:  2009-03-16       Impact factor: 5.157

8.  Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons.

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Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-08       Impact factor: 11.205

9.  Biallelic MADD variants cause a phenotypic spectrum ranging from developmental delay to a multisystem disorder.

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Journal:  Brain       Date:  2020-08-01       Impact factor: 13.501

Review 10.  Basic mechanisms for recognition and transport of synaptic cargos.

Authors:  Max A Schlager; Casper C Hoogenraad
Journal:  Mol Brain       Date:  2009-08-04       Impact factor: 4.041
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