Literature DB >> 12388737

The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules.

Margo H Furman1, Neelendu Dey, Domenico Tortorella, Hidde L Ploegh.   

Abstract

Human cytomegalovirus (HCMV) US10 encodes a glycoprotein that binds to major histocompatibility complex (MHC) class I heavy chains. While expression of US10 delays the normal trafficking of MHC class I molecules out of the endoplasmic reticulum, US10 does not obviously facilitate or inhibit the action of two other HCMV-encoded MHC class I binding proteins, US2 and US11.

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Year:  2002        PMID: 12388737      PMCID: PMC136774          DOI: 10.1128/jvi.76.22.11753-11756.2002

Source DB:  PubMed          Journal:  J Virol        ISSN: 0022-538X            Impact factor:   5.103


  17 in total

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Journal:  J Virol       Date:  1995-08       Impact factor: 5.103

10.  Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11.

Authors:  D J Schust; D Tortorella; J Seebach; C Phan; H L Ploegh
Journal:  J Exp Med       Date:  1998-08-03       Impact factor: 14.307

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10.  Human cytomegalovirus US2 causes similar effects on both major histocompatibility complex class I and II proteins in epithelial and glial cells.

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