P Pillet1, F Boralévi, J F Chateil, E Pinlou, D Lacombe. 1. Service de pédiatrie générale et rhumatologie pédiatrique, hôpital Pellegrin-Enfants, place Amélie-Raba-Léon, 33076 Bordeaux, France. pascal.pillet@chu-bordeaux.fr
Abstract
CASE REPORT: Two brothers with a Currarino's disease are reported. Patients characteristics included a dysmorphic syndrome, cranial suture defects, hypertrophic osteoarthropathy and severe chronic eczema. COMMENTS: Consanguinity of parents suggests an autosomal recessive inheritance. CONCLUSION: Currarino's disease is a rare unknown constitutional syndrome. The age of beginning of the disease, the cranial suture defects and the chronic eczema allow to distinguish it from the others primary hypertrophic osteoarthropathies.
CASE REPORT: Two brothers with a Currarino's disease are reported. Patients characteristics included a dysmorphic syndrome, cranial suture defects, hypertrophic osteoarthropathy and severe chronic eczema. COMMENTS: Consanguinity of parents suggests an autosomal recessive inheritance. CONCLUSION:Currarino's disease is a rare unknown constitutional syndrome. The age of beginning of the disease, the cranial suture defects and the chronic eczema allow to distinguish it from the others primary hypertrophic osteoarthropathies.
Authors: Wenke Seifert; Julia Beninde; Katrin Hoffmann; Tom H Lindner; Christian Bassir; Fuat Aksu; Christoph Hübner; Nienke E Verbeek; Stefan Mundlos; Denise Horn Journal: Eur J Hum Genet Date: 2009-07-01 Impact factor: 4.246