Literature DB >> 12386291

Renotropic role and therapeutic potential of HGF in the kidney.

Kunio Matsumoto1, Toshikazu Nakamura.   

Abstract

Hepatocyte growth factor (HGF) has mitogenic, morphogenic and anti-apoptotic activities on renal epithelial cells, and is a potential renotropin for renal regeneration. In chronic renal failure/fibrosis, HGF in the kidney declines in a manner reciprocal to the increase in transforming growth factor-beta (TGF-beta). Neutralization of HGF by the antibody leads to acceleration of renal failure/fibrosis, while HGF administration leads to remarkable attenuation, thus indicating the importance of the balance between HGF and TGF-beta in the pathogenesis and therapy of chronic renal failure. HGF is strongly considered as potential treatment for acute and chronic renal failure.

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Year:  2002        PMID： 12386291     DOI： 10.1093/ndt/17.suppl_9.59

Source DB:  PubMed          Journal:  Nephrol Dial Transplant        ISSN： 0931-0509            Impact factor:   5.992


  4 in total

1.  Urinary biomarkers are associated with incident cardiovascular disease, all-cause mortality and deterioration of kidney function in type 2 diabetic patients with microalbuminuria.

Authors:  Bernt Johan von Scholten; Henrik Reinhard; Tine W Hansen; Jens Oellgaard; Hans-Henrik Parving; Peter K Jacobsen; Peter Rossing
Journal:  Diabetologia       Date:  2016-03-31       Impact factor: 10.122

2.  Renal primordia activate kidney regenerative events in a rat model of progressive renal disease.

Authors:  Barbara Imberti; Daniela Corna; Paola Rizzo; Christodoulos Xinaris; Mauro Abbate; Lorena Longaretti; Paola Cassis; Valentina Benedetti; Ariela Benigni; Carlamaria Zoja; Giuseppe Remuzzi; Marina Morigi
Journal:  PLoS One       Date:  2015-03-26       Impact factor: 3.240

3.  Ethanol Extract of Centella asiatica (Gotu Kola) Attenuates Tubular Injury Through Inhibition of Inflammatory Cytokines and Enhancement of Anti-Fibrotic Factor in Mice with 5/6 Subtotal Nephrectomy.

Authors:  Nur Arfian; Wiwit Ananda Wahyu Setyaningsih; Nungki Anggorowati; Muhammad Mansyur Romi; Dwi Cahyani Ratna Sari
Journal:  Malays J Med Sci       Date:  2019-11-04

4.  Conditioned mesenchymal stem cells attenuate progression of chronic kidney disease through inhibition of epithelial-to-mesenchymal transition and immune modulation.

Authors:  Jei-Wen Chang; Hsin-Lin Tsai; Chang-Wei Chen; Hui-Wen Yang; An-Hang Yang; Ling-Yu Yang; Paulus S Wang; Yee-Yung Ng; Teng-Lung Lin; Oscar K Lee
Journal:  J Cell Mol Med       Date:  2012-12       Impact factor: 5.310
  4 in total

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