Literature DB >> 12385051

[Prophylactic prescription of low-molecular-weight heparin in the non-surgical setting: impact of recommendations].

J P Fagot1, A Flahault, M Fodil, A Kanfer, S Alamowitch, J P Haymann, I Lecomte, H Lioté, A Parrot, J Rossert, E Verdy, A Becker.   

Abstract

OBJECTIVE: Low-molecular-weight heparins (LMWH) had official approval for use for venous thromboembolism prophylaxis only for surgery patients when this survey was conducted, but were nevertheless often used in non-surgery patients. We conducted this "before and after" survey from May 1998 to April 1999 to assess the impact of the recommendations implemented in the beginning of 1999.
METHODS: Data on the use of LMWH were collected on three different days within a three week interval in all non-surgery departments at the Tenon hospital before distribution of expert recommendations early in 1999. Published in La Presse Médicale in January 2000, these recommendations issued from an external panel of 43 experts who were contacted to establish a consensus opinion using the Delphi method. Data were again collected on three different days after implementation of the recommendations. Implementation was based on a patient-specific prescription order form requested by the hospital pharmacy for delivery to the department.
RESULTS: Data were collected for 121 prescriptions prior to the recommendations and for 158 after. Sex-ratio, mean age and percentage of LMWH prescriptions did not differ significantly between the two periods. There was a lower number of non-appropriate prescriptions after implementation of the recommendations from 54.5% to 35.4% (p = 0.01) with better conformity for recommendation A (high-risk patients) (36% versus 43%, NS) and for recommendation B (= 2 risk situations or = 1 risk situation and = 2 aggravating factors) (10% versus 22%, p = 0.01). Better conformity of LMWH prescriptions in oncology and radiotherapy departments partially explained this general improvement, but the difference remained significant when excluding these two departments (p = 0.04).
CONCLUSION: This study shows that physician compliance with recognized expert recommendations can improve their implementation. This procedure is now in general use in the Tenon hospital.

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Year:  2001        PMID: 12385051

Source DB:  PubMed          Journal:  Presse Med        ISSN: 0755-4982            Impact factor:   1.228


  4 in total

Review 1.  A systematic review of strategies to improve prophylaxis for venous thromboembolism in hospitals.

Authors:  Rebecca Tooher; Philippa Middleton; Clarabelle Pham; Robert Fitridge; Siohban Rowe; Wendy Babidge; Guy Maddern
Journal:  Ann Surg       Date:  2005-03       Impact factor: 12.969

2.  Modifications of low-molecular weight heparin use in a French university hospital after implementation of new guidelines.

Authors:  Sophie Leclerc-Foucras; Haleh Bagheri; Kamran Samii; Jean-Louis Montastruc; Maryse Lapeyre-Mestre
Journal:  Drug Saf       Date:  2007       Impact factor: 5.606

3.  Agreement of four competing guidelines on prevention of venous thromboembolism and comparison with observed physician practices: a cross-sectional study of 1,032 medical inpatients.

Authors:  José Labarère; Jean-Luc Bosson; Jean-François Bergmann; Nathalie Thilly
Journal:  J Gen Intern Med       Date:  2004-08       Impact factor: 5.128

4.  Results of a venous thromboembolism prophylaxis program for hospitalized patients.

Authors:  Luiz Francisco Cardoso; Daniella Vianna C Krokoscz; Edison Ferreira de Paiva; Ilka Spinola Furtado; Jorge Mattar; Marcia Martiniano de Souza E Sá; Antonio Carlos Onofre de Lira
Journal:  Vasc Health Risk Manag       Date:  2016-12-12
  4 in total

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