Literature DB >> 12384792

Mitochondrial DNA 5178A polymorphism and longevity.

Yong-Gang Yao1, Qing-Peng Kong, Ya-Ping Zhang.   

Abstract

Previous studies have shown that mitochondrial DNA (mtDNA) 5178 adenine/cytosine (5178A) polymorphism, which is one of the haplogroup-specific mutations for mtDNA haplogroup D, was apparently associated with aging and longevity in humans. We genotyped the 5178A in 293 samples representing three age groups (Old, n=95; Young, n=103; and Infant, n=95) from Yunnan Province, China. The distribution frequency of the 5178A in the Old samples (16.84%) is slightly higher than in those of the Young (13.59%) and Infant (15.79%), but the frequency difference between the age groups is far from being statistically significant ( P>0.05). Our results fail to support the suggestion of association between mtDNA 5178A (or haplogroup D) and longevity.

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Year:  2002        PMID： 12384792     DOI： 10.1007/s00439-002-0826-z

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  17 in total

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4.  A reappraisal of complete mtDNA variation in East Asian families with hearing impairment.

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Review 5.  Genetic epidemiology in aging research.

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10.  Phylogeographic analysis of mitochondrial DNA haplogroup F2 in China reveals T12338C in the initiation codon of the ND5 gene not to be pathogenic.

Authors:  Qing-Peng Kong; Yong-Gang Yao; Chang Sun; Chun-Ling Zhu; Li Zhong; Cheng-Ye Wang; Wang-Wei Cai; Xiang-Min Xu; An-Long Xu; Ya-Ping Zhang
Journal:  J Hum Genet       Date:  2004-07-22       Impact factor: 3.172
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