Literature DB >> 12384373

Stampidine is a potent inhibitor of Zidovudine- and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical human immunodeficiency virus type 1 isolates with thymidine analog mutations.

Fatih M Uckun1, Sharon Pendergrass, T K Venkatachalam, Sanjive Qazi, Douglas Richman.   

Abstract

We report the antiretroviral activity of stavudine-5'-(p-bromophenyl methoxyalaninyl phosphate) (stampidine [STAMP]), a novel aryl phosphate derivative of stavudine, against primary clinical human immunodeficiency virus type 1 (HIV-1) isolates. STAMP inhibited each one of nine clinical HIV-1 isolates of non-B envelope subtype and 20 genotypically and phenotypically nucleoside analog reverse transcriptase inhibitor-resistant HIV-1 isolates at subnanomolar to low-nanomolar concentrations.

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Year:  2002        PMID： 12384373      PMCID： PMC128707          DOI： 10.1128/AAC.46.11.3613-3616.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives.

Authors:  J Balzarini; A Karlsson; S Aquaro; C F Perno; D Cahard; L Naesens; E De Clercq; C McGuigan
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-09       Impact factor: 11.205

2.  Phosphoramidate derivatives of d4T as inhibitors of HIV: the effect of amino acid variation.

Authors:  C McGuigan; H W Tsang; D Cahard; K Turner; S Velazquez; A Salgado; L Bidois; L Naesens; E De Clercq; J Balzarini
Journal:  Antiviral Res       Date:  1997-08       Impact factor: 5.970

3.  Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds.

Authors:  J Balzarini; P Herdewijn; E De Clercq
Journal:  J Biol Chem       Date:  1989-04-15       Impact factor: 5.157

4.  Antiretrovirus specificity and intracellular metabolism of 2',3' -didehydro-2',3'-dideoxythymidine (stavudine) and its 5'-monophosphate triester prodrug So324.

Authors:  J Balzarini; H Egberink; K Hartmann; D Cahard; T Vahlenkamp; H Thormar; E De Clercq; C McGuigan
Journal:  Mol Pharmacol       Date:  1996-11       Impact factor: 4.436

5.  TXU (anti-CD7)-pokeweed antiviral protein as a potent inhibitor of human immunodeficiency virus.

Authors:  F M Uckun; L M Chelstrom; L Tuel-Ahlgren; I Dibirdik; J D Irvin; M C Langlie; D E Myers
Journal:  Antimicrob Agents Chemother       Date:  1998-02       Impact factor: 5.191

6.  Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite.

Authors:  C McGuigan; D Cahard; H M Sheeka; E De Clercq; J Balzarini
Journal:  J Med Chem       Date:  1996-04-12       Impact factor: 7.446

7.  Toxicity and pharmacokinetics of stampidine in mice and rats.

Authors:  Fatih M Uckun; Chun-Lin Chen; Elizabeth Lisowski; Greg C Mitcheltree; Taracad K Venkatachalam; Douglas Erbeck; Hao Chen; Barbara Waurzyniak
Journal:  Arzneimittelforschung       Date:  2003

8.  D4T-5'-[p-bromophenyl methoxyalaninyl phosphate] as a potent and non-toxic anti-human immunodeficiency virus agent.

Authors:  R Vig; T K Venkatachalam; F M Uckun
Journal:  Antivir Chem Chemother       Date:  1998-09

9.  Enhancing effects of a mono-bromo substitution at the para position of the phenyl moiety on the metabolism and anti-HIV activity of d4T-phenyl methoxyalaninyl phosphate derivatives.

Authors:  T K Venkatachalam; H L Tai; R Vig; C L Chen; S T Jan; F M Uckun
Journal:  Bioorg Med Chem Lett       Date:  1998-11-17       Impact factor: 2.823

10.  The emerging genetic diversity of HIV. The importance of global surveillance for diagnostics, research, and prevention.

Authors:  D J Hu; T J Dondero; M A Rayfield; J R George; G Schochetman; H W Jaffe; C C Luo; M L Kalish; B G Weniger; C P Pau; C A Schable; J W Curran
Journal:  JAMA       Date:  1996-01-17       Impact factor: 56.272
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  6 in total

1.  In vivo toxicity, pharmacokinetics, and anti-human immunodeficiency virus activity of stavudine-5'-(p-bromophenyl methoxyalaninyl phosphate) (stampidine) in mice.

Authors:  Fatih M Uckun; Sanjive Qazi; Sharon Pendergrass; Elizabeth Lisowski; Barbara Waurzyniak; Chun-Lin Chen; T K Venkatachalam
Journal:  Antimicrob Agents Chemother       Date:  2002-11       Impact factor: 5.191

2.  Conceival, a novel noncontraceptive vaginal vehicle for lipophilic microbicides.

Authors:  Osmond J D'Cruz; Peter Samuel; Fatih M Uckun
Journal:  AAPS PharmSciTech       Date:  2005-09-20       Impact factor: 3.246

3.  Bifunctional inhibition of HIV-1 reverse transcriptase: a first step in designing a bifunctional triphosphate.

Authors:  Dongyuan Piao; Aravind Basavapathruni; Pinar Iyidogan; Guangxiu Dai; Wolfgang Hinz; Adrian S Ray; Eisuke Murakami; Joy Y Feng; Fei You; Ginger E Dutschman; David J Austin; Kathlyn A Parker; Karen S Anderson
Journal:  Bioorg Med Chem Lett       Date:  2012-12-20       Impact factor: 2.823

Review 4.  Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases.

Authors:  Lars Petter Jordheim; David Durantel; Fabien Zoulim; Charles Dumontet
Journal:  Nat Rev Drug Discov       Date:  2013-06       Impact factor: 84.694

5.  In vivo antiretroviral activity of stampidine in chronically feline immunodeficiency virus-infected cats.

Authors:  Fatih M Uckun; Chun-Lin Chen; Peter Samuel; Sharon Pendergrass; T K Venkatachalam; Barbara Waurzyniak; Sanjive Qazi
Journal:  Antimicrob Agents Chemother       Date:  2003-04       Impact factor: 5.191

6.  Stampidine prevents mortality in an experimental mouse model of viral hemorrhagic fever caused by lassa virus.

Authors:  Fatih M Uckun; Alexander S Petkevich; Alexei O Vassilev; Heather E Tibbles; Leonid Titov
Journal:  BMC Infect Dis       Date:  2004-01-13       Impact factor: 3.090
  6 in total

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