Literature DB >> 12384261

NMDA receptor-mediated mechanism of ketamine-induced facilitation of glutamatergic excitatory synaptic transmission.

Eichi Narimatsu1, Yurie Kawamata, Mikito Kawamata, Naoyuki Fujimura, Akiyoshi Namiki.   

Abstract

The effect of ketamine on CA1-field EPSPs (fEPSPs) in rat hippocampal slices was investigated. Ketamine (100 microM) facilitated fEPSPs at 0.05 Hz. The fEPSP facilitation was suppressed completely by AP-5 and partially by propranolol, and also by an increase in stimulation frequency. These results indicate that ketamine facilitates excitatory synaptic transmission by activating NMDA receptors via beta-adrenoceptors under conditions in which NMDA receptor channel block is slight.

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Year:  2002        PMID： 12384261     DOI： 10.1016/s0006-8993(02)03375-9

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  5 in total

Review 1.  Glutamatergic model psychoses: prediction error, learning, and inference.

Authors:  Philip R Corlett; Garry D Honey; John H Krystal; Paul C Fletcher
Journal:  Neuropsychopharmacology       Date:  2010-09-22       Impact factor: 7.853

2.  Precision rodent whisker stimulator with integrated servo-locked control and displacement measurement.

Authors:  Jennifer L Walker; Fernanda Monjaraz-Fuentes; Christi R Pedrow; David M Rector
Journal:  J Neurosci Methods       Date:  2010-12-15       Impact factor: 2.390

3.  (2R,6R)-hydroxynorketamine exerts mGlu2 receptor-dependent antidepressant actions.

Authors:  Panos Zanos; Jaclyn N Highland; Brent W Stewart; Polymnia Georgiou; Carleigh E Jenne; Jacqueline Lovett; Patrick J Morris; Craig J Thomas; Ruin Moaddel; Carlos A Zarate; Todd D Gould
Journal:  Proc Natl Acad Sci U S A       Date:  2019-03-13       Impact factor: 11.205

4.  Ketamine effects on memory reconsolidation favor a learning model of delusions.

Authors:  Philip R Corlett; Victoria Cambridge; Jennifer M Gardner; Jennifer S Piggot; Danielle C Turner; Jessica C Everitt; Fernando Sergio Arana; Hannah L Morgan; Amy L Milton; Jonathan L Lee; Michael R F Aitken; Anthony Dickinson; Barry J Everitt; Anthony R Absalom; Ram Adapa; Naresh Subramanian; Jane R Taylor; John H Krystal; Paul C Fletcher
Journal:  PLoS One       Date:  2013-06-12       Impact factor: 3.240

5.  Connection changes in somatosensory cortex induced by different doses of propofol.

Authors:  Zhaoduan Li; Xingkui Liu; Yi Zhang; Jinshan Shi; Yu Zhang; Peng Xie; Tian Yu
Journal:  PLoS One       Date:  2014-02-07       Impact factor: 3.240
  5 in total

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