G C Chua1, Y Y Sitoh, C C Lim, H C Chua, P Y Ng. 1. Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore, Republic of Singapore. cgc99@hotmail.com
Abstract
OBJECTIVES: Osmotic myelinolysis is a distinctive clinical syndrome with characteristic CT and MR features. This study was undertaken to determine the MR appearance of these lesions on T1 and T2-weighted, and diffusion-weighted imaging (DWI) sequences with apparent diffusion coefficient (ADC) mapping. MATERIALS AND METHODS: We describe six patients who presented with deranged serum sodium levels and subsequently developed osmotic myelinolysis. CT and MRI scans were retrospectively reviewed, including the advanced functional MR sequence of DWI with ADC mapping. RESULTS: Both cerebral white matter and pontine lesions were typically hypo and hyper-intense on T1 and T2W sequences respectively. Lesions were mildly hyperintense on isotropic DWI images with elevation of the ADC. CONCLUSION: MRI is superior to CT in depicting lesions in osmotic myelinolysis. DWI with ADC mapping suggests that osmotic myelinolysis is not simply a demyelinating disorder but has similarities to multiple sclerosis.
OBJECTIVES:Osmotic myelinolysis is a distinctive clinical syndrome with characteristic CT and MR features. This study was undertaken to determine the MR appearance of these lesions on T1 and T2-weighted, and diffusion-weighted imaging (DWI) sequences with apparent diffusion coefficient (ADC) mapping. MATERIALS AND METHODS: We describe six patients who presented with deranged serum sodium levels and subsequently developed osmotic myelinolysis. CT and MRI scans were retrospectively reviewed, including the advanced functional MR sequence of DWI with ADC mapping. RESULTS: Both cerebral white matter and pontine lesions were typically hypo and hyper-intense on T1 and T2W sequences respectively. Lesions were mildly hyperintense on isotropic DWI images with elevation of the ADC. CONCLUSION: MRI is superior to CT in depicting lesions in osmotic myelinolysis. DWI with ADC mapping suggests that osmotic myelinolysis is not simply a demyelinating disorder but has similarities to multiple sclerosis.
Authors: A Förster; I Nölte; H Wenz; M Al-Zghloul; H U Kerl; C Brockmann; M A Brockmann; C Groden Journal: Neuroradiology Date: 2012-08-30 Impact factor: 2.804
Authors: Frank Donnerstag; Xiaoqi Ding; Lars Pape; Eva Bültmann; Thomas Lücke; Jan Zajaczek; Ludwig Hoy; Anibh Martin Das; Heinrich Lanfermann; Jochen Ehrich; Hans Hartmann Journal: Eur Radiol Date: 2011-10-08 Impact factor: 5.315