Insights from yeast endosomes.

The endosomal system of yeast is simpler than that of animal cells, but as it is mapped more similarities are emerging. A key role for ubiquitin in sorting proteins to and into multivesicular bodies has been demonstrated. The finding that Phox homology domains recognise phosphatidylinositol 3-phosphate explains how sorting nexins are recruited to endosomes, where they mediate the retrieval of membrane proteins from the endocytic pathway.