Literature DB >> 12383120

The kinetics of the removal of the N-methyltrityl (Mtt) group during the synthesis of branched peptides.

D Li1, D L Elbert.   

Abstract

The purpose of this short communication is to describe the reaction rate for the removal of the N-methyltrityl (Mtt) protecting group that is used in solid-phase peptide synthesis for the production of branched and cyclic peptides. The reaction rate was observed to follow zero-order kinetics, and we suggest the optimal conditions for the removal of the Mtt group in batchwise synthesis.

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Year:  2002        PMID： 12383120     DOI： 10.1034/j.1399-3011.2002.21018.x

Source DB:  PubMed          Journal:  J Pept Res        ISSN： 1397-002X


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