Literature DB >> 12381657

Large intracoronary thrombi with good TIMI flow during acute myocardial infarction: four cases of successful aggressive medical management in patients without angiographically detectable coronary atherosclerosis.

F Burzotta1, M Hamon, R Sabatier, F Prati, A Boccanelli, G Grollier.   

Abstract

Four cases of young patients with acute myocardial infarction are discussed in which urgent angiography showed large intracoronary thrombus and TIMI (thrombolysis in myocardial infarction) flow > or = 2 in the infarct related artery. The rest of the coronary tree appeared to be free of detectable atherosclerosis. Percutaneous transluminal coronary angioplasty was not performed and an aggressive antiplatelet/anticoagulant treatment was administered (acetylsalicylic acid, clopidogrel, abciximab, and heparin). In all cases early angiographic control (1-12 days after AMI) showed disappearance of thrombus, no significant residual stenosis, and normal flow. No deterioration of left ventricular function was observed and the clinical course both in hospital and at five months' follow up was uneventful.

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Year:  2002        PMID： 12381657      PMCID： PMC1767422          DOI： 10.1136/heart.88.5.e6

Source DB:  PubMed          Journal:  Heart        ISSN： 1355-6037            Impact factor:   5.994


  12 in total

1.  1999 update: ACC/AHA Guidelines for the Management of Patients With Acute Myocardial Infarction: Executive Summary and Recommendations: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction).

Authors:  T J Ryan; E M Antman; N H Brooks; R M Califf; L D Hillis; L F Hiratzka; E Rapaport; B Riegel; R O Russell; E E Smith; W D Weaver; R J Gibbons; J S Alpert; K A Eagle; T J Gardner; A Garson; G Gregoratos; S C Smith
Journal:  Circulation       Date:  1999-08-31       Impact factor: 29.690

Review 2.  Recognition of the importance of embolization in atherosclerotic vascular disease.

Authors:  E J Topol; J S Yadav
Journal:  Circulation       Date:  2000-02-08       Impact factor: 29.690

3.  Conservative management of patients with acute myocardial infarction and spontaneous acute patency of the infarct-related artery.

Authors:  P G Steg; D Himbert; H Benamer; G Karrillon; A Boccara; P Aubry; J M Juliard
Journal:  Am Heart J       Date:  1997-08       Impact factor: 4.749

4.  Increased prevalence of the G20210A prothrombin gene variant in acute coronary syndromes without metabolic or acquired risk factors or with limited extent of disease.

Authors:  F Burzotta; K Paciaroni; V De Stefano; P Chiusolo; A Manzoli; I Casorelli; A M Leone; E Rossi; G Leone; A Maseri; F Andreotti
Journal:  Eur Heart J       Date:  2002-01       Impact factor: 29.983

5.  Combination therapy with abciximab reduces angiographically evident thrombus in acute myocardial infarction: a TIMI 14 substudy.

Authors:  C M Gibson; J A de Lemos; S A Murphy; S J Marble; C H McCabe; C P Cannon; E M Antman; E Braunwald
Journal:  Circulation       Date:  2001-05-29       Impact factor: 29.690

6.  Reappraising the role of immediate intervention following thrombolytic recanalization in acute myocardial infarction.

Authors:  E D Grech; A G Sutton; P G Campbell; V J Ashton; D J Price; J A Hall; M A de Belder
Journal:  Am J Cardiol       Date:  2000-08-15       Impact factor: 2.778

7.  The effect of intravenous thrombolytic therapy on left ventricular function: a report on tissue-type plasminogen activator and streptokinase from the Thrombolysis in Myocardial Infarction (TIMI Phase I) trial.

Authors:  F H Sheehan; E Braunwald; P Canner; H T Dodge; J Gore; P Van Natta; E R Passamani; D O Williams; B Zaret
Journal:  Circulation       Date:  1987-04       Impact factor: 29.690

8.  Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death. Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion.

Authors:  E Falk
Journal:  Circulation       Date:  1985-04       Impact factor: 29.690

Review 9.  Current issues in reperfusion therapy.

Authors:  B J Gersh
Journal:  Am J Cardiol       Date:  1998-10-22       Impact factor: 2.778

10.  Early effects of tissue-type plasminogen activator added to conventional therapy on the culprit coronary lesion in patients presenting with ischemic cardiac pain at rest. Results of the Thrombolysis in Myocardial Ischemia (TIMI IIIA) Trial.

Authors: 
Journal:  Circulation       Date:  1993-01       Impact factor: 29.690
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