Literature DB >> 12379729

The N-terminal domain of RTX toxin ApxI of Actinobacillus pleuropneumoniae elicits protective immunity in mice.

J N Seah1, J Frey, J Kwang.   

Abstract

We expressed three Actinobacillus pleuropneumoniae ApxI deletion derivatives to map the domain that could induce protective immunity. Antiserum to ApxI N-terminal covered by residues 40 to 380 was found to neutralize ApxI hemolytic activity but not ApxIII cytotoxicity. When used as a subunit vaccine in mice, this recombinant N-terminal fragment elicited protection against lethal infection with heterologous A. pleuropneumoniae serovars.

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Year:  2002        PMID： 12379729      PMCID： PMC130407          DOI： 10.1128/IAI.70.11.6464-6467.2002

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  31 in total

1.  Identification and characterization of a porcine-specific transferrin receptor in Actinobacillus pleuropneumoniae.

Authors:  G C Gonzalez; D L Caamano; A B Schryvers
Journal:  Mol Microbiol       Date:  1990-07       Impact factor: 3.501

2.  Endobronchial inoculation with Apx toxins of Actinobacillus pleuropneumoniae leads to pleuropneumonia in pigs.

Authors:  E M Kamp; N Stockhofe-Zurwieden; L A van Leengoed; M A Smits
Journal:  Infect Immun       Date:  1997-10       Impact factor: 3.441

3.  Domains of Escherichia coli hemolysin (HlyA) involved in binding of calcium and erythrocyte membranes.

Authors:  D F Boehm; R A Welch; I S Snyder
Journal:  Infect Immun       Date:  1990-06       Impact factor: 3.441

Review 4.  Virulence attributes of the liposaccharides of the HAP group organisms.

Authors:  B W Fenwick
Journal:  Can J Vet Res       Date:  1990-04       Impact factor: 1.310

5.  The repeat domain of Escherichia coli haemolysin (HlyA) is responsible for its Ca2+-dependent binding to erythrocytes.

Authors:  A Ludwig; T Jarchau; R Benz; W Goebel
Journal:  Mol Gen Genet       Date:  1988-11

6.  Calcium is required for binding of Escherichia coli hemolysin (HlyA) to erythrocyte membranes.

Authors:  D F Boehm; R A Welch; I S Snyder
Journal:  Infect Immun       Date:  1990-06       Impact factor: 3.441

7.  Grouping of Actinobacillus pleuropneumoniae strains of serotypes 1 through 12 on the basis of their virulence in mice.

Authors:  J P Komal; K R Mittal
Journal:  Vet Microbiol       Date:  1990-11       Impact factor: 3.293

8.  Nucleotide sequence of the hemolysin I gene from Actinobacillus pleuropneumoniae.

Authors:  J Frey; R Meier; D Gygi; J Nicolet
Journal:  Infect Immun       Date:  1991-09       Impact factor: 3.441

9.  Immune responses to the lipopolysaccharides and capsular polysaccharides of Haemophilus pleuropneumoniae in convalescent and immunized pigs.

Authors:  B W Fenwick; B I Osburn
Journal:  Infect Immun       Date:  1986-11       Impact factor: 3.441

10.  Virulence properties and protective efficacy of the capsular polymer of Haemophilus (Actinobacillus) pleuropneumoniae serotype 5.

Authors:  T J Inzana; J Ma; T Workman; R P Gogolewski; P Anderson
Journal:  Infect Immun       Date:  1988-08       Impact factor: 3.441
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  12 in total

1.  N-terminus of flagellin enhances vaccine efficacy against Actinobacillus pleuropneumoniae.

Authors:  Kamonpun Chuekwon; Chun-Yen Chu; Li-Ting Cheng
Journal:  BMC Vet Res       Date:  2022-07-16       Impact factor: 2.792

2.  Functional pentameric formation via coexpression of the Escherichia coli heat-labile enterotoxin B subunit and its fusion protein subunit with a neutralizing epitope of ApxIIA exotoxin improves the mucosal immunogenicity and protection against challenge by Actinobacillus pleuropneumoniae.

Authors:  Jung-Mi Kim; Seung-Moon Park; Jung-Ae Kim; Jin-Ah Park; Min-Hee Yi; Nan-Sun Kim; Jong-Lye Bae; Sung Goo Park; Yong-Suk Jang; Moon-Sik Yang; Dae-Hyuk Kim
Journal:  Clin Vaccine Immunol       Date:  2011-10-26

3.  Immunoproteomic analysis of bacterial proteins of Actinobacillus pleuropneumoniae serotype 1.

Authors:  Wei Zhang; Jing Shao; Guangjin Liu; Fang Tang; Yan Lu; Zhipeng Zhai; Yang Wang; Zongfu Wu; Huochun Yao; Chengping Lu
Journal:  Proteome Sci       Date:  2011-06-26       Impact factor: 2.480

4.  Type IV fimbrial subunit protein ApfA contributes to protection against porcine pleuropneumonia.

Authors:  Lenka Sadilkova; Jiri Nepereny; Vladimir Vrzal; Peter Sebo; Radim Osicka
Journal:  Vet Res       Date:  2012-01-12       Impact factor: 3.683

5.  In silico prediction of Gallibacterium anatis pan-immunogens.

Authors:  Ragnhild J Bager; Egle Kudirkiene; Isabelle da Piedade; Torsten Seemann; Tine K Nielsen; Susanne E Pors; Andreas H Mattsson; John D Boyce; Ben Adler; Anders M Bojesen
Journal:  Vet Res       Date:  2014-08-08       Impact factor: 3.683

6.  Draft Genome Sequence of the Virulent Avibacterium paragallinarum Serotype A Strain JF4211 and Identification of Two Toxins.

Authors:  Lisandra Aguilar-Bultet; Sandra P Calderon-Copete; Joachim Frey; Laurent Falquet
Journal:  Genome Announc       Date:  2013-08-15

7.  Recombinant tandem epitope vaccination provides cross protection against Actinobacillus pleuropneumoniae challenge in mice.

Authors:  Jiameng Xiao; Jianfang Liu; Chuntong Bao; Rining Zhu; Jingmin Gu; Changjiang Sun; Xin Feng; Chongtao Du; Wenyu Han; Yang Li; Liancheng Lei
Journal:  AMB Express       Date:  2020-07-08       Impact factor: 3.298

8.  Polymorphism analysis of the apxIA gene of Actinobacillus pleuropneumoniae serovar 5 isolated in swine herds from Brazil.

Authors:  Lucas Fernando Dos Santos; Richard Costa Polveiro; Thalita Scatamburlo Moreira; Pedro Marcus Pereira Vidigal; Yung-Fu Chang; Maria Aparecida Scatamburlo Moreira
Journal:  PLoS One       Date:  2018-12-18       Impact factor: 3.240

9.  Global Gene Networks in 3D4/31 Porcine Alveolar Macrophages Treated with Antigenic Epitopes of Actinobacillus pleuropneumoniae ApxIA, IIA, and IVA.

Authors:  Suji Kim; Myung Whan Oh; Woo Bin Park; Han Sang Yoo
Journal:  Sci Rep       Date:  2019-03-27       Impact factor: 4.379

10.  Enhancement of protective immune responses by oral vaccination with Saccharomyces cerevisiae expressing recombinant Actinobacillus pleuropneumoniae ApxIA or ApxIIA in mice.

Authors:  Sung Jae Shin; Seung Won Shin; Mi Lan Kang; Deog Yong Lee; Moon-Sik Yang; Yong-Suk Jang; Han Sang Yoo
Journal:  J Vet Sci       Date:  2007-12       Impact factor: 1.672
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