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Literature DB >> 12379638

Role of interleukin 15 and interleukin 18 in inflammatory response.

Abstract

Interleukin 15 (IL15) and interleukin 18 (IL18) are cytokines produced principally by macrophages during innate immune response and subsequently profoundly influence adaptive immunity. Recent studies have shown that IL15 and IL18 play an influential part in inflammatory response. Here we present recent data mainly from our own laboratories illustrating the importance of IL15 and IL18 in the induction and perpetuation of chronic inflammation during experimental and clinical rheumatoid synovitis.

Entities: Disease Gene

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Year: 2002 PMID： 12379638 PMCID： PMC1766710 DOI： 10.1136/ard.61.suppl_2.ii100

Source DB: PubMed Journal: Ann Rheum Dis ISSN： 0003-4967 Impact factor: 19.103

28 in total

1. A role for IL-15 in rheumatoid arthritis?

Authors: M H Shah; K V Hackshaw; M A Caligiuri
Journal: Nat Med Date: 1998-06 Impact factor: 53.440

2. Interleukin 15: a proinflammatory role in rheumatoid arthritis synovitis.

Authors: I B McInnes; F Y Liew
Journal: Immunol Today Date: 1998-02

3. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis.

Authors: I B McInnes; B P Leung; R D Sturrock; M Field; F Y Liew
Journal: Nat Med Date: 1997-02 Impact factor: 53.440

4. Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology.

Authors: H Ruchatz; B P Leung; X Q Wei; I B McInnes; F Y Liew
Journal: J Immunol Date: 1998-06-01 Impact factor: 5.422

5. Increased expression of IL-15 in the synovium of patients with rheumatoid arthritis compared with patients with Yersinia-induced arthritis and osteoarthritis.

Authors: E W Thurkow; I M van der Heijden; F C Breedveld; T J Smeets; M R Daha; P M Kluin; A E Meinders; P P Tak
Journal: J Pathol Date: 1997-04 Impact factor: 7.996

6. Expression and cleavage of tumor necrosis factor-alpha and tumor necrosis factor receptors by human monocytic cell lines upon direct contact with stimulated T cells.

Authors: E Vey; D Burger; J M Dayer
Journal: Eur J Immunol Date: 1996-10 Impact factor: 5.532

7. Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells In vitro and in the SCID mouse-human rheumatoid arthritis model In vivo.

Authors: N Oppenheimer-Marks; R I Brezinschek; M Mohamadzadeh; R Vita; P E Lipsky
Journal: J Clin Invest Date: 1998-03-15 Impact factor: 14.808

8. Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.

Authors: X Zhang; S Sun; I Hwang; D F Tough; J Sprent
Journal: Immunity Date: 1998-05 Impact factor: 31.745

9. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation.

Authors: J P Lodolce; D L Boone; S Chai; R E Swain; T Dassopoulos; S Trettin; A Ma
Journal: Immunity Date: 1998-11 Impact factor: 31.745

10. Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice.

Authors: P Kanakaraj; K Ngo; Y Wu; A Angulo; P Ghazal; C A Harris; J J Siekierka; P A Peterson; W P Fung-Leung
Journal: J Exp Med Date: 1999-04-05 Impact factor: 14.307

20 in total

1. A molecular and functional analysis of large granular lymphocyte expansions in patients with chronic myelogenous leukemia treated with tyrosine kinase inhibitors.

Authors: John J Powers; Jason A Dubovsky; P K Epling-Burnette; Lynn Moscinski; Ling Zhang; Satu Mustjoki; Eduardo M Sotomayor; Javier A Pinilla-Ibarz
Journal: Leuk Lymphoma Date: 2011-01-27

Review 2. New strategies to control inflammatory synovitis: interleukin 15 and beyond.

Authors: I B McInnes; J A Gracie; M Harnett; W Harnett; F Y Liew
Journal: Ann Rheum Dis Date: 2003-11 Impact factor: 19.103

3. Clinical significance of IL-18, IL-15, IL-12 and TNF-alpha measurement in rheumatoid arthritis.

Authors: Ljiljana Petrovic-Rackov; Nada Pejnovic
Journal: Clin Rheumatol Date: 2005-12-14 Impact factor: 2.980

4. Serum interleukin-18 levels in patients with Behçet's disease. Is its expression associated with disease activity or clinical presentations?

Authors: U Musabak; S Pay; H Erdem; I Simsek; A Pekel; A Dinc; A Sengul
Journal: Rheumatol Int Date: 2005-10-05 Impact factor: 2.631

Review 5. Mediators of inflammation in acute kidney injury.

Authors: Ali Akcay; Quocan Nguyen; Charles L Edelstein
Journal: Mediators Inflamm Date: 2010-02-21 Impact factor: 4.711

6. Association of polymorphisms in the human IL-10 and IL-18 genes with rheumatoid arthritis.

Authors: Binwu Ying; Yunying Shi; Xiaofu Pan; Xingbo Song; Zhunchun Huang; Qian Niu; Bei Cai; Lanlan Wang
Journal: Mol Biol Rep Date: 2010-04-28 Impact factor: 2.316

7. Haploidentical natural killer cells induce remissions in non-Hodgkin lymphoma patients with low levels of immune-suppressor cells.

Authors: Veronika Bachanova; Dhifaf Sarhan; Todd E DeFor; Sarah Cooley; Angela Panoskaltsis-Mortari; Bruce R Blazar; Julie M Curtsinger; Linda Burns; Daniel J Weisdorf; Jeffrey S Miller
Journal: Cancer Immunol Immunother Date: 2017-12-07 Impact factor: 6.968