Literature DB >> 12379614

Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?

M Feldmann1, E Andreakos, C Smith, J Bondeson, S Yoshimura, S Kiriakidis, C Monaco, C Gasparini, S Sacre, A Lundberg, E Paleolog, N J Horwood, F M Brennan, B M J Foxwell.   

Abstract

There is increasing evidence that NF-kappaB is a major, if not the major transcription factor regulating inflammation and immunity. While this implies that blocking NF-kappaB might be therapeutically beneficial, it raises clear questions regarding the balance between efficacy and safety. In this brief review we discuss the effects of NF-kappaB blockade in rheumatoid arthritis, inflammation and immunity, and consider possible therapeutic targets within the NF-kappaB family.

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Year:  2002        PMID： 12379614      PMCID： PMC1766706          DOI： 10.1136/ard.61.suppl_2.ii13

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  23 in total

1.  Adenovirus-mediated expression of a mutant IkappaB kinase 2 inhibits the response of endothelial cells to inflammatory stimuli.

Authors:  W Oitzinger; R Hofer-Warbinek; J A Schmid; Y Koshelnick; B R Binder; R de Martin
Journal:  Blood       Date:  2001-03-15       Impact factor: 22.113

2.  Nuclear factor-kappaB activation in alveolar macrophages requires IkappaB kinase-beta, but not nuclear factor-kappaB inducing kinase.

Authors:  Matthew Conron; Evangelos Andreakos; Panagiotis Pantelidis; Clive Smith; Huw L C Beynon; Roland M Dubois; Brian M J Foxwell
Journal:  Am J Respir Crit Care Med       Date:  2002-04-01       Impact factor: 21.405

3.  High efficiency gene transfer is an efficient way of defining therapeutic targets: a functional genomics approach.

Authors:  B M Foxwell; S Yoshimura; J Bondeson; F M Brennan; M Feldmann
Journal:  Ann Rheum Dis       Date:  2001-11       Impact factor: 19.103

4.  Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines.

Authors:  S Yoshimura; J Bondeson; B M Foxwell; F M Brennan; M Feldmann
Journal:  Int Immunol       Date:  2001-05       Impact factor: 4.823

5.  TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion.

Authors:  Cathleen J Ciesielski; Evangelos Andreakos; Brian M J Foxwell; Marc Feldmann
Journal:  Eur J Immunol       Date:  2002-07       Impact factor: 5.532

6.  Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism.

Authors:  R Sen; D Baltimore
Journal:  Cell       Date:  1986-12-26       Impact factor: 41.582

7.  Role of NFkappaB in antigen presentation and development of regulatory T cells elucidated by treatment of dendritic cells with the proteasome inhibitor PSI.

Authors:  S Yoshimura; J Bondeson; F M Brennan; B M Foxwell; M Feldmann
Journal:  Eur J Immunol       Date:  2001-06       Impact factor: 5.532

8.  Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynucleotides as a gene therapy.

Authors:  T Tomita; E Takeuchi; N Tomita; R Morishita; M Kaneko; K Yamamoto; T Nakase; H Seki; K Kato; Y Kaneda; T Ochi
Journal:  Arthritis Rheum       Date:  1999-12

9.  NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.

Authors:  C Smith; E Andreakos; J B Crawley; F M Brennan; M Feldmann; B M Foxwell
Journal:  J Immunol       Date:  2001-11-15       Impact factor: 5.422

10.  Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators.

Authors:  J Bondeson; B Foxwell; F Brennan; M Feldmann
Journal:  Proc Natl Acad Sci U S A       Date:  1999-05-11       Impact factor: 11.205
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  17 in total

Review 1.  Sumoylation modulates oxidative stress relevant to the viability and functionality of pancreatic beta cells.

Authors:  Ping Yang; Shuang Hu; Fei Yang; Xiang-Qian Guan; Shi-Qiang Wang; Ping Zhu; Fei Xiong; Shu Zhang; Junfa Xu; Qi-Lin Yu; Cong-Yi Wang
Journal:  Am J Transl Res       Date:  2014-07-18       Impact factor: 4.060

2.  Lipopolysaccharide and hypoxia significantly alters interleukin-8 and macrophage chemoattractant protein-1 production by human fibroblasts but not fibrosis related factors.

Authors:  T Eleftheriadis; V Liakopoulos; B Lawson; G Antoniadi; I Stefanidis; G Galaktidou
Journal:  Hippokratia       Date:  2011-07       Impact factor: 0.471

3.  Bilberry juice modulates plasma concentration of NF-kappaB related inflammatory markers in subjects at increased risk of CVD.

Authors:  Anette Karlsen; Ingvild Paur; Siv K Bøhn; Amrit K Sakhi; Grethe I Borge; Mauro Serafini; Iris Erlund; Petter Laake; Serena Tonstad; Rune Blomhoff
Journal:  Eur J Nutr       Date:  2010-02-02       Impact factor: 5.614

Review 4.  Interleukins and interleukin receptors in rheumatoid arthritis: Research, diagnostics and clinical implications.

Authors:  Lili Magyari; Dalma Varszegi; Erzsebet Kovesdi; Patricia Sarlos; Bernadett Farago; Andras Javorhazy; Katalin Sumegi; Zsolt Banfai; Bela Melegh
Journal:  World J Orthop       Date:  2014-09-18

5.  Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFkappaB.

Authors:  M Asif Amin; Christian S Haas; Kui Zhu; Pamela J Mansfield; Michael J Kim; Nicholas P Lackowski; Alisa E Koch
Journal:  Blood       Date:  2005-11-29       Impact factor: 22.113

6.  Kruppel-like factor 2 is a transcriptional regulator of chronic and acute inflammation.

Authors:  Lalitha Nayak; Lediana Goduni; Yoichi Takami; Nikunj Sharma; Parul Kapil; Mukesh K Jain; Ganapati H Mahabeleshwar
Journal:  Am J Pathol       Date:  2013-03-13       Impact factor: 4.307

7.  Effects of hyaluronan on carrageenan-induced synovitis in rat TMJ.

Authors:  Min-Jung Lee; Kook-Jin Han; Hyuk-Jae Kwon; Han-Sung Jung; Sung-Won Cho
Journal:  Anat Cell Biol       Date:  2010-06-30

8.  High levels of Lymphotoxin-Beta (LT-Beta) gene expression in rheumatoid arthritis synovium: clinical and cytokine correlations.

Authors:  Killian P O'Rourke; G O'Donoghue; C Adams; H Mulcahy; C Molloy; C Silke; M Molloy; F Shanahan; F O'Gara
Journal:  Rheumatol Int       Date:  2008-04-01       Impact factor: 2.631

9.  Anti-arthritic effects of magnolol in human interleukin 1β-stimulated fibroblast-like synoviocytes and in a rat arthritis model.

Authors:  Jyh-Horng Wang; Kao-Shang Shih; Jing-Ping Liou; Yi-Wen Wu; Anita Shin-Yuan Chang; Kang-Li Wang; Ching-Lin Tsai; Chia-Ron Yang
Journal:  PLoS One       Date:  2012-02-16       Impact factor: 3.240

10.  Isocitrate dehydrogenase 2 inhibits gastric cancer cell invasion via matrix metalloproteinase 7.

Authors:  Dandan Wu
Journal:  Tumour Biol       Date:  2015-11-10
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